PMID: 18193783Sep 1, 1995Paper

Method of information synthesis--meta analysis of endomyocardial biopsy complications

Srpski arhiv za celokupno lekarstvo
R MaksimovićA Ristić

Abstract

The "information explosion" in the last 20 years has created a need for technique that synthesizes information from various sources. One of the methods for synthetasing information from various independent but similar studies is meta analysis. The aim of this study was to estimate complication rate of endomyocardial biopsy and therefore to assess its routine clinical applicability. In order to identify published studies regarding endomyocardial biopsy between 1980-1993, we performed computer and manual literature search. A total of 255 papers were retrieved but only 18 studies fulfilled separately predefined inclusion/exclusion criteria for meta analysis of complications. For each study, numerical weights were calculated according to the sample size and magnitude of effect size (proportion of each of the observed diagnostic categories). Weighted average of proportions was used to obtain a 95 posto study-specific confidence interval (CI) for each category. To compare incidence of complications of endomyocardial biopsy of the right to the endomyocardial biopsy of the left ventricle, modified Mantel-Haenszel test of the effect size for summarizing data from individual studies was used. Complication rate in analyzed studies was com...Continue Reading

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