Method validation for determination of arsenic, cadmium, chromium and lead in milk by means of dynamic reaction cell inductively coupled plasma mass spectrometry

Analytica Chimica Acta
S D'IlioN Violante

Abstract

With Regulation No. 1881/2006 the European Union fixed a maximum level for lead in milk. Consequently, there is the need to determine very low concentration of elements that may be present in milk in trace and ultratrace levels. Quadrupole inductively coupled plasma mass spectrometry (Q-ICP-MS) combined with dynamic reaction cell (DRC) has been widely employed in order to reach very low concentration, requested for this product. Furthermore, the DRC technology can help in removing polyatomic and argon-based interferences. In the present study, a method for the determination of arsenic, cadmium, chromium and lead in bovine milk was validated according to the EU common standards by means of DRC-ICP-MS. The main parameters evaluated in the validation were: recovery, repeatability and within-laboratory reproducibility, detection and quantification limits, linearity range and measurement uncertainty. Additionally, stability studies of the analyte in solution and ruggedness studies were carried out. The results obtained for limit of detection (LoD) and limit of quantification (LoQ) in microg kg(-1) were respectively: As, 3.1 and 9.5; Cd, 0.08 and 0.24; Cr, 0.229 and 0.693; Pb, 0.5 and 1.5. While for the recovery: As, 91%; Cd 96%; Cr ...Continue Reading

References

Apr 6, 2002·Nutrition·Olaf WappelhorstBernd Markert

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Citations

Jan 19, 2012·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·A P Nascimento NetoM C C Melo
Dec 9, 2010·International Journal of Environmental Research and Public Health·Clarissa S P De CastroJosé G Dórea
Nov 21, 2015·Food Additives & Contaminants. Part B, Surveillance·Dong-Gyu KimSeong-Wan Son
May 7, 2014·The Science of the Total Environment·Elena De FelipAlessandro di Domenico
Aug 22, 2017·Biological Trace Element Research·Xue-Yin QuWen-Ju Zhang
Sep 7, 2017·Environmental Science and Pollution Research International·Emmanouil EvgenakisKonstantinos Fytianos
Jan 26, 2018·Journal of Food Protection·Daniele ConficoniValerio Giaccone
Sep 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maria Luisa AstolfiSilvia Canepari

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