Methodologic approaches to studying environmental factors in childhood cancer

Environmental Health Perspectives
S Grufferman

Abstract

Little is known about environmental causes of childhood cancer. This is probably due to the relative rarity of cancer in children. In the United States, cancer incidence in adults is over 20 times greater than cancer incidence in children. The situation is compounded by the fact that two groups of cancers, leukemias and brain and spinal tumors, account for half of all childhood cancers. The rarity of childhood cancer renders the conduct of most cohort studies infeasible. The majority of studies assessing potential environmental risk factors for childhood cancers have been case-control studies, which are highly efficient for studying rare diseases. Case-control studies of childhood cancers have been greatly facilitated by using cooperative clinical trial groups for case identification. The national studies that have emerged utilize random-digit telephone dialing and telephone interviewing as feasible and economic means of identifying and interviewing controls. Other approaches such as descriptive epidemiology, ecologic studies, and studies of cancer clusters have proven to be disappointing in elucidating environmental causes of childhood cancer. Descriptive and ecologic studies provide no information on specific exposures of stu...Continue Reading

References

Apr 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·A G Knudson
Apr 15, 1971·The New England Journal of Medicine·A L HerbstD C Poskanzer
Sep 1, 1983·Medical Hypotheses·S GruffermanG Michalopoulos
Jun 1, 1984·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S GruffermanE R Delong
May 21, 1982·JAMA : the Journal of the American Medical Association·F P Li, J F Fraumeni
Jun 1, 1996·Journal of Epidemiology and Community Health·E G Knox, E A Gilman
Jun 28, 1958·British Medical Journal·A STEWARTD HEWITT

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Citations

Jul 1, 1998·Environmental Health Perspectives·S H Zahm, M H Ward
Oct 9, 2004·Environmental Health Perspectives·Lawrence P HanrahanJoseph Olson
Apr 25, 2007·Critical Reviews in Clinical Laboratory Sciences·Richard L Tower, Logan G Spector

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