Methodological deficits in diagnostic research using '-omics' technologies: evaluation of the QUADOMICS tool and quality of recently published studies.

PloS One
Lucy A ParkerIldefonso Hernández-Aguado

Abstract

QUADOMICS is an adaptation of QUADAS (a quality assessment tool for use in systematic reviews of diagnostic accuracy studies), which takes into account the particular challenges presented by '-omics' based technologies. Our primary objective was to evaluate the applicability and consistency of QUADOMICS. Subsequently we evaluated and describe the methodological quality of a sample of recently published studies using the tool. 45'-omics'-based diagnostic studies were identified by systematic search of Pubmed using suitable MeSH terms ("Genomics", "Sensitivity and specificity", "Diagnosis"). Three investigators independently assessed the quality of the articles using QUADOMICS and met to compare observations and generate a consensus. Consistency and applicability was assessed by comparing each reviewer's original rating with the consensus. Methodological quality was described using the consensus rating. Agreement was above 80% for all three reviewers. Four items presented difficulties with application, mostly due to the lack of a clearly defined gold standard. Methodological quality of our sample was poor; studies met roughly half of the applied criteria (mean +/- sd, 54.7+/-18.4%). Few studies were carried out in a population th...Continue Reading

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Methods Mentioned

BETA
ELISA
PCR

Software Mentioned

SE
STATA
QUADAS
QUADOMICS

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