PMID: 6969693Jan 1, 1980Paper

Methodological implications of testing anaerobe susceptibility to cephalosporins (cefazolin, cefamandole, cefoxitin)

Infection
C KrasemannJ Ungerechts

Abstract

By simultaneously performing broth dilution, agar dilution, and agar diffusion tests with Bacteroidaceae and Peptococcaceae, the influence of methodology upon the outcome of susceptibility testing to cefazolin, cefamandole and cefoxitin was studied. With beta-lactamase positive and negative Bacteroidaceae, the results of the broth dilution and agar dilution tests were in good agreement for cefoxitin. However, when tested with cefaxolin and cefamandole, beta-lactamase positive Bacteroides strains had mostly high broth dilution MICs and relatively low agar dilution MICs. The statistical analysis of the relationship between zone size and broth dilution or agar dilution MICs frequently showed lack of stochastic linearity or relatively low correlation coefficients.

References

Mar 1, 1978·Antimicrobial Agents and Chemotherapy·M L Britz, R G Wilkinson
May 1, 1976·Antimicrobial Agents and Chemotherapy·E C ErnstF P Tally
Oct 1, 1976·Antimicrobial Agents and Chemotherapy·V L Sutter, S M Finegold
Jan 1, 1971·Medical Microbiology and Immunology·H WernerH Hussels

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