Methodological issues in trials of complementary and alternative medicine interventions.

Nursing Research
Alla SikorskiiMohammad Hossein Rahbar

Abstract

Complementary and alternative medicine (CAM) use is widespread among cancer patients. Information on safety and efficacy of CAM therapies is needed for both patients and healthcare providers. Well-designed randomized clinical trials of CAM therapy interventions can inform both clinical research and practice. The aim of this study was to review important issues that affect the design of randomized clinical trials for CAM interventions. Using the methods component of the Consolidated Standards for Reporting Trials as a guiding framework and a National Cancer Institute-funded reflexology study as an exemplar, methodological issues related to participants, intervention, objectives, outcomes, sample size, randomization, blinding, and statistical methods were reviewed. Trials of CAM interventions designed and implemented according to appropriate methodological standards will facilitate the needed scientific rigor in CAM research. Interventions in CAM can be tested using proposed methodology, and the results of testing will inform nursing practice in providing safe and effective supportive care and in improving the well-being of patients.

Associated Clinical Trials

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Citations

Apr 13, 2013·International Journal of Nursing Practice·Anne VaajokiKatri Vehviläinen-Julkunen
Jun 16, 2012·Journal of Pain and Symptom Management·Alla SikorskiiSuzie Ahn
Jan 1, 2012·Forschende Komplementärmedizin = Research in Complementary Medicine·H Felix FischerBenno Brinkhaus
Jun 23, 2020·Topics in Magnetic Resonance Imaging : TMRI·Kai J BormStephanie E Combs
May 14, 2021·Complementary Therapies in Medicine·Nimet Karatas, Aysegul Isler Dalgic
Aug 18, 2021·Inquiry : a Journal of Medical Care Organization, Provision and Financing·Jamie L WoodBrian G Southwell

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