Methodological standardization for a multi-institutional in vivo trial of localized 31P MR spectroscopy in human cancer research. In vitro and normal volunteer studies

NMR in Biomedicine
Fernando Arias-MendozaCooperative Group on MRS Applications in Cancer

Abstract

A multi-institutional group has been created to demonstrate the utility of in vivo 31P magnetic resonance spectroscopy (31P-MRS) to study human cancers in vivo. This review is concerned with the novel problems concerning quality control in this large multinational trial of 31P MRS. Our results show that the careful and systematic performance of the quality control tests depicted here (standardized dual 1H/31P tuned radiofrequency probe, quality control procedures, routine use of 1H irradiation while acquiring 31P MR signals) has ensured comparable results between the different institutions. In studies made in vitro, the root-mean-square error was 3.6 %, and in muscle of healthy volunteers in vivo the coefficients of variance for the ratios phosphocreatine/nucleotide-triphosphates, phosphocreatine/noise and nucleotide-triphosphate/noise were 12.2, 7.0 and 10.8 %, respectively. The standardization of the acquisition protocol for in vivo-localized 31P MR spectroscopy across the different institutions has resulted in comparable in vivo data, decreasing the possible problems related to a research study carried out under a multi-institutional setting.

Citations

Feb 21, 2014·Expert Review of Anticancer Therapy·Heinrich Florian MagometschniggKatja Pinker
Jun 28, 2012·PET Clinics·Seung-Cheol LeeJerry D Glickson
Jun 18, 2010·European Journal of Radiology·K PinkerT H Helbich
Jul 18, 2009·Academic Radiology·Sanjeev ChawlaHarish Poptani
Jul 21, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kristen L ZakianYuman Fong
Mar 10, 2009·Journal of Cellular and Molecular Medicine·Natalie J SerkovaDouglas J Kominsky
Jan 30, 2007·Journal of Magnetic Resonance Imaging : JMRI·Chris Boesch
Sep 21, 2006·NMR in Biomedicine·Susan M Galbraith
Mar 30, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·W BognerS Gruber
Mar 25, 2011·NMR in Biomedicine·Dennis W J KlompPeter R Luijten
Mar 10, 2012·Radiation Research·Dominick J O McIntyreJohn R Griffiths
Apr 4, 2012·Molecular Oncology·Moritz F KircherSteven M Larson

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