Methodology and measurement of the effectiveness of Haemophilus influenzae type b vaccine: systematic review

Vaccine
Rosalyn O'LoughlinKim Mulholland

Abstract

The use of the highly effective Haemophilus influenzae type b (Hib) conjugate vaccine has increased globally. We review the benefits and limitations of studies measuring Hib vaccine effectiveness (VE). We critically examine the case-control approach by assessing the similarities and differences in methodology and findings and discuss the need for future Hib VE studies. In the absence of good surveillance data, vaccine effectiveness studies can play an important role, particularly with the increasing use of pneumococcal vaccine that has not been well tested under field conditions in less developed countries. However, the effectiveness of Hib vaccine has been well documented so the need for future VE Hib studies is minimal.

References

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Citations

Apr 18, 2014·Proceedings. Biological Sciences·T J D Knight-JonesD J Paton
Mar 19, 2013·Research in Developmental Disabilities·Laurence GermanyCatherine Arnaud
Jun 21, 2013·The Journal of Pediatrics·Rana HajjehMathuram Santosham
Jun 26, 2012·Vaccine·Anita H J van den Biggelaar, William S Pomat
Oct 20, 2017·Human Vaccines & Immunotherapeutics·Guijun NingWeizhong Yang
Mar 24, 2016·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Alka KhaitanDerya Unutmaz
Jun 21, 2013·The Journal of Pediatrics·Asif Raza KhowajaUNKNOWN Pakistan Hib Vaccine Study Group
Aug 12, 2021·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Yuji OtakiKenta Ito

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