PMID: 16502655Mar 1, 2006Paper

Methodology for predicting oxygen transport on an intravenous membrane oxygenator combining computational and analytical models

Journal of Biomechanical Engineering
AMADOR M. GuzmánCRISTINA H. Amon

Abstract

A computational methodology for accurately predicting flow and oxygen-transport characteristics and performance of an intravenous membrane oxygenator (IMO) device is developed, tested, and validated. This methodology uses extensive numerical simulations of three-dimensional computational models to determine flow-mixing characteristics and oxygen-transfer performance, and analytical models to indirectly validate numerical predictions with experimental data, using both blood and water as working fluids. Direct numerical simulations for IMO stationary and pulsating balloons predict flow field and oxygen transport performance in response to changes in the device length, number of and balloon pulsation frequency. Multifiber models are used to investigate interfiber interference and length effects for a stationary balloon whereas a single fiber model is used to analyze the effect of balloon pulsations on velocity and oxygen concentration fields and to evaluate oxygen transfer rates. An analytical lumped model is developed and validated by comparing its numerical predictions with experimental data. Numerical results demonstrate that oxygen transfer rates for a stationary balloon regime decrease with increasing number of fibers, indepe...Continue Reading

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Aug 3, 2005·Journal of Biomechanical Engineering·Amador M GuzmánCristina H Amon

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