Methodology of detailed dosimetry and treatment of uncertainty and variations for in vivo studies

Bioelectromagnetics
Niels KusterWolfgang Kainz

Abstract

Detailed and accurate dosimetric information is a basic precondition for acquiring adequate interpretations and valuations of in vivo studies testing radiofrequency (RF) electromagnetic fields (EMF). Instantaneous locally induced fields depend on many parameters, for example, orientation of the animal with respect to the incident field, animal size and posture, and tissue distribution. These parameters are often constrained, resulting in significant uncertainties in the dosimetric assessment of the exposure, averaged over all animals and the entire experimental phase, as well as in significant variations of the local exposures during the experiment. A sufficient analysis should therefore include (1) average and peak spatial specific absorption rate (SAR) values for the whole body and specific organs, (2) the uncertainty of each assessed SAR value, and (3) the short term and long term SAR variations between the tissues of individual animals. A methodology to obtain this pertinent information is developed and proposed in this paper. Using this methodology the dosimetry of a rat exposure apparatus operating at the carrier frequency of 1747 MHz, previously developed for a 2-year bioassay study within the European Union project PERF...Continue Reading

Citations

Oct 5, 2006·Bioelectromagnetics·Thomas TillmannClemens Dasenbrock
Apr 25, 2013·Bioelectromagnetics·Serena FiocchiTheodoros Samaras
Sep 22, 2010·Bioelectromagnetics·Arne LowdenBengt Arnetz
Mar 3, 2011·Bioelectromagnetics·Bor KosPeter Gajšek
Apr 13, 2012·Bioelectromagnetics·Siriwat WasoontarajaroenPascale V Bellier
Nov 10, 2013·Bioelectromagnetics·Bor KosPeter Gajšek
Apr 3, 2016·Bioelectromagnetics·Myles CapstickNiels Kuster
Jun 14, 2012·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Richard A M CantersGerard C van Rhoon
Mar 25, 2015·BioMed Research International·A PaffiM Liberti
Oct 24, 2009·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·R A M CantersG C Van Rhoon
Sep 25, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Manuel MurbachNiels Kuster
Jul 21, 2016·Physics in Medicine and Biology·A CollinP Leveque
Apr 15, 2009·International Journal of Radiation Biology·Christina ZiemannClemens Dasenbrock
Oct 12, 2021·Frontiers in Physiology·Sofwatul Mokhtarah MaluinSiti Fatimah Ibrahim
Oct 19, 2021·Frontiers in Public Health·Xianghui WangJie Zhang

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