Methodology of the Cardiovascular Health and Age-Related Maculopathy (CHARM) Study

Ophthalmic Epidemiology
Luba D RobmanC A McCarty

Abstract

Age-related macular degeneration (AMD) is responsible for the majority of visual impairment in the Western world. Epidemiological studies examining risk factors for AMD are needed to develop strategies for the prevention of blindness from this condition. A number of potentially modifiable risk factors for AMD have been identified; however, only smoking has been a consistent risk factor across the numerous studies. A growing body of evidence suggests that AMD and cardiovascular disease may have common risk factors. The Cardiovascular Health and Age Related Maculopathy (CHARM) Study was established to examine the risk factors for AMD and its progression, in particular risk factors associated with cardiovascular disease. Examining risk factors for prevalent AMD, cases with AMD were compared with age and gender matched controls with no AMD features. For the assessment of AMD progression, the study examined in 2001 and 2002 those participants with early AMD, or age-related maculopathy (ARM), who had undergone baseline examination between 1992 and 1995 and compared the characteristics of those who had progression of AMD with those who did not. The CHARM study involved both ophthalmic and cardiovascular examinations. Standardised clin...Continue Reading

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Citations

Jan 1, 2009·Journal of Ophthalmology·Paul P ConnellStephen Beatty
Apr 4, 2013·American Journal of Epidemiology·Amy C CohnRobyn H Guymer
Nov 11, 2011·Current Eye Research·Rasa LiutkevicieneAbdonas Tamosiunas
Mar 26, 2015·Mechanisms of Ageing and Development·Daniela GradinaruGabriel Ioan Prada
Feb 16, 2007·Clinical & Experimental Ophthalmology·Robyn Guymer, Luba Robman
Aug 29, 2007·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Luba RobmanRobyn Guymer
Dec 15, 2016·Acta Ophthalmologica·Antonio PinnaGiuliana Solinas
May 20, 2005·American Journal of Epidemiology·Luba RobmanRobyn Guymer

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