Methods and models for percutaneous absorption studies of organophosphates

Pathologie-biologie
I BoudryG Lallement

Abstract

Organophosphates are highly toxic compounds, mainly penetrating the organism through the percutaneous route. In this context, having topical skin protectant capable of limitating their percutaneous penetration is of crucial importance for exposed people. Knowledge of the toxicokinetic parameters corresponding to the percutaneous penetration of these compounds is a key step for the development of these protective formulations. The different experimental approaches, in vivo and ex vivo, used to predict percutaneous penetration of these toxics are presented. The relevance and reliability of cutaneous experimental models are analysed.

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Citations

Oct 28, 2014·Journal of Applied Toxicology : JAT·Eui Chang Jung, Howard I Maibach
Dec 2, 2011·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Izumi KajiAtsukazu Kuwahara
May 31, 2012·Photochemistry and Photobiology·Corinne Miquel-JeanjeanHélène Duplan

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