Methods and potential biomarkers for the evaluation of endothelial dysfunction in chronic kidney disease: a critical approach

Journal of the American Society of Hypertension : JASH
Simona M HogasAdrian Covic

Abstract

The impressive cardiovascular morbidity and mortality of chronic kidney disease (CKD) patients is attributable in a significant proportion to endothelial dysfunction (ED), arterial stiffness, and vascular calcifications. Abnormal vascular reactivity in these patients is more pronounced compared with other high-risk populations, but remains undiagnosed in the usual clinical setting. We briefly review the most important causes and risk factors of ED, oxidative stress, and inflammation related to arterial stiffness. We describe the main methods of ED investigation and the importance of using potential biomarkers together with classic techniques for a more comprehensive assessment of this condition. These methods include evaluation of: forearm blood flow by plethysmography, skin microcirculation by laser Doppler, and flow-mediated vasodilation by Doppler ultrasound imaging. Applanation tonometry is an easy-to-handle tool that allows a clinically reliable assessment of arterial stiffness and is also useful in quantifying endothelium-dependent and -independent vascular reactivity. We also discuss the diagnostic and therapeutic impact of new markers of ED in the CKD population. Improvement of endothelial function is an important chall...Continue Reading

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Citations

Mar 23, 2012·International Urology and Nephrology·Mehmet KanbayAdrian Covic
Feb 5, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kevin S HeffernanVandana Menon
Aug 23, 2011·Clinical and Experimental Nephrology·Tomonori KimuraYoshitaka Isaka
Jun 19, 2014·Kidney International·Dalia El-GamalGunther Marsche
Oct 29, 2010·Journal of the American Society of Hypertension : JASH·Koji YamamotoGenjiro Kimura
Jan 19, 2012·Circulation. Cardiovascular Imaging·Guillaume MahéPierre Abraham
Mar 29, 2019·The Journal of Vascular Access·Giulio DistefanoAntonio Granata
Sep 23, 2014·American Journal of Physiology. Renal Physiology·Jelena KlawitterRobert W Schrier
Apr 8, 2018·Clinical Science·Montserrat Baldan-MartinGema Ruiz-Hurtado
Mar 29, 2021·European Journal of Clinical Investigation·Marieta P TheodorakopoulouPantelis Sarafidis
Apr 21, 2021·Expert Review of Respiratory Medicine·Marieta P TheodorakopoulouAfroditi K Boutou
Dec 5, 2019·Kidney & Blood Pressure Research·Domingo HernándezMiguel Gonzalez-Molina

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