Methods and Reporting Studies Assessing Fecal Microbiota Transplantation: A Systematic Review

Annals of Internal Medicine
Aïda BafetaPhilippe Ravaud

Abstract

Fecal microbiota transplantation (FMT) could be a novel treatment option for several chronic diseases associated with altered gut microbiota. To examine the conduct and reporting of studies assessing FMT. Cochrane Central Register of Controlled Trials, PubMed, EMBASE, and Web of Science from inception to 31 January 2017. Two reviewers independently examined titles and abstracts to identify all English-language reports of human clinical studies assessing the safety or efficacy of FMT. Three reviewers independently assessed study types and characteristics and the reporting of important methodological components of the FMT intervention. Most (84%) of the 85 published reports found addressed the use of FMTs for Clostridium difficile infection or inflammatory bowel disease, and most (87%) were non-randomized controlled trials. Important methodological components that were not reported in published studies included the following: eligibility criteria for donors (47%), materials used for collecting stools and the period of collection (96%), methods used for conservation of stools (76%), the amount and type of stools used (for example, fresh or frozen), and duration of stool conservation (67%). Many (58%) did not report an analysis of ...Continue Reading

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