Methods and risk of bias in molecular marker prognosis studies in oral squamous cell carcinoma

Oral Diseases
J SHahinas, D Hysi

Abstract

We investigated methods and risk of bias, focusing on research design, aim, prognostic factors, outcome, and statistical analysis in molecular marker prognosis studies of oral squamous cell carcinoma. We used a database search strategy to indentify relevant articles published in English in 2016. We developed a data extraction form to assess and extract information on methods of molecular marker prognosis studies in oral squamous cell carcinoma, based on methodological recommendations for prognosis studies. We used the Quality in Prognosis Studies tool to assess the risk of bias in six domains. Thirty-six papers were retrieved for full text review: 35 were replication prognosis factor studies and one was a model development based only on molecular markers to stratify patient's risk. Retrospective cohort was the design used in most studies (91%). Despite recommendations against dichotomizing continuous prognostic variables, this was observed in the majority of cases. A substantial number of studies (60%) conducted survival analysis, COX regression, and Kaplan-Meier. Prognostic variables included in the multivariate model were often preselected based on the results of univariable analysis. Risk of bias was assessed high for confou...Continue Reading

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