Methods and tools for comparative genomics of foodborne pathogens.

Foodborne Pathogens and Disease
Arvind A Bhagwat, Medha Bhagwat

Abstract

A comparison of genome sequences and of encoded proteins with the database of existing annotated sequences is a useful approach to understand the information at the genome level. Here we demonstrate the utility of several DNA and protein sequence comparison tools to interpret the information obtained from several genome projects. Comparisons are presented between closely related strains of Escherichia coli commensal isolates, different isolates of O157:H7, and Shigella spp. It is expected that comparative genome analysis will generate a wealth of data to compare pathogenic isolates with varying levels of pathogenicity, which in turn may reveal mechanisms by which the pathogen may adapt to a particular nutrient supply in certain foods. These genome sequence analysis tools will strengthen foodborne pathogen surveillance and subsequent risk assessment to enhance the safety of the food supply.

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Citations

Dec 8, 2010·Archives of Microbiology·Kelvin GohArvind A Bhagwat
Jun 10, 2011·Journal of Basic Microbiology·Yushan HuShouyi Chen
Jan 1, 2010·Annual Review of Food Science and Technology·M Begley, Colin Hill
Feb 11, 2015·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Beth M Cleveland, Meghan L Manor
Apr 3, 2015·The American Journal of Clinical Nutrition·Kerry L IveyRichard L Prince
Jun 19, 2015·Nutrition Reviews·Julia J PetersonMarjorie L McCullough

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