Apr 2, 2020

Characterization and treatment of SARS-CoV-2 in nasal and bronchial human airway epithelia

BioRxiv : the Preprint Server for Biology
Gali HousmanM. Rosa-Calatrava

Abstract

In the current COVID-19 pandemic context, proposing and validating effective treatments represents a major challenge. However, the lack of biologically relevant pre-clinical experimental models of SARS-CoV-2 infection as a complement of classic cell lines represents a major barrier for scientific and medical progress. Here, we advantageously used human reconstituted airway epithelial models of nasal or bronchial origin to characterize viral infection kinetics, tissue-level remodeling of the cellular ultrastructure and transcriptional immune signatures induced by SARS-CoV-2. Our results underline the relevance of this model for the preclinical evaluation of antiviral candidates. Foremost, we provide evidence on the antiviral efficacy of remdesivir and the therapeutic potential of the remdesivir-diltiazem combination as a rapidly available option to respond to the current unmet medical need imposed by COVID-19.

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Mentioned in this Paper

Vertebrates
Genome
RNA, Untranslated
Protein Biosynthesis
Evaluation
Long Intergenic Non-Protein Coding RNA
RNA, Long Untranslated
Transcript
Peptides
Computed (Procedure)

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