Methods for evaluation of urinary excretion parameters of alclofenac after I.M. administration of its water soluble lysine salt in man

European Journal of Drug Metabolism and Pharmacokinetics
R Testa, R Latini

Abstract

The urinary excretion data after I.M. administration of water soluble lysine salt of Alclofenac were analysed by the techniques suggested by Niebergall, Wagner, Martin and Cummings. All methods used give similar estimates of both DU infinity and Kel with exception of the "Sigma minus" method when DU infinity obtained by "Rate Method" was utilized. Niebergall's method is preferred on the basis that it provides an accurate estimation of both DU infinity and Kel. These parameters, evaluated after administration of Alclofenac-lysinate, resulted in agreement with previously reported data obtained after administration of different pharmaceuticals of acidic drug.

References

Oct 1, 1987·Journal of Pharmaceutical Sciences·K Humphries, G Dryhurst
Apr 1, 1990·European Journal of Drug Metabolism and Pharmacokinetics·I SzinaiA Magyar
Jan 1, 1981·Virchows Archiv. A, Pathological Anatomy and Histology·A C Wenink

Citations

Apr 1, 1978·Clinical Pharmacology and Therapeutics·L T SennelloN Friedman
Jan 1, 1975·Current Medical Research and Opinion·L F Wiggins
Oct 1, 1975·Journal of Pharmaceutical Sciences·P J NiebergallR L Schnaare
Dec 1, 1973·European Journal of Clinical Pharmacology·M S BenedettiC Nagant de Deuxchaisnes
Feb 1, 1967·British Journal of Pharmacology and Chemotherapy·A J CummingsB K Martin
Feb 1, 1967·British Journal of Pharmacology and Chemotherapy·B K Martin

Related Concepts

Study, Methodological
Glucuronic Acids
Lysine
Soluble
Phenylacetic Acids
Body Excretions
Excretory Function
Alclofenac
Urine Lysine Measurement
Acids

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