Methods for evaluation of urinary excretion parameters of alclofenac after I.M. administration of its water soluble lysine salt in man

European Journal of Drug Metabolism and Pharmacokinetics
R Testa, R Latini


The urinary excretion data after I.M. administration of water soluble lysine salt of Alclofenac were analysed by the techniques suggested by Niebergall, Wagner, Martin and Cummings. All methods used give similar estimates of both DU infinity and Kel with exception of the "Sigma minus" method when DU infinity obtained by "Rate Method" was utilized. Niebergall's method is preferred on the basis that it provides an accurate estimation of both DU infinity and Kel. These parameters, evaluated after administration of Alclofenac-lysinate, resulted in agreement with previously reported data obtained after administration of different pharmaceuticals of acidic drug.


Oct 1, 1987·Journal of Pharmaceutical Sciences·K Humphries, G Dryhurst
Apr 1, 1990·European Journal of Drug Metabolism and Pharmacokinetics·I SzinaiA Magyar
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Apr 1, 1978·Clinical Pharmacology and Therapeutics·L T SennelloN Friedman
Jan 1, 1975·Current Medical Research and Opinion·L F Wiggins
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Related Concepts

Study, Methodological
Glucuronic Acids
Phenylacetic Acids
Body Excretions
Excretory Function
Urine Lysine Measurement

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