Methods for functional assessment after C7 spinal cord hemisection in the rhesus monkey.

Neurorehabilitation and Neural Repair
Yvette S NoutJacqueline C Bresnahan

Abstract

Reliable outcome measures are essential for preclinical modeling of spinal cord injury (SCI) in primates. need to be sensitive to both increases and decreases in function in order to demonstrate potential positive or negative effects of therapeutics. To develop behavioral tests and analyses to assess recovery of function after SCI in the nonhuman primate. In all, 24 male rhesus macaques were subjected to complete C7 lateral hemisection. The authors scored recovery of function in an open field and during hand tasks in a restraining chair. In addition, EMG analyses were performed in the open field, during hand tasks, and while animals walked on a treadmill. Both control and treated monkeys that received candidate therapeutics were included in this report to determine whether the behavioral assays were capable of detecting changes in function over a wide range of outcomes. The behavioral assays are shown to be sensitive to detecting a wide range of motor functional outcomes after cervical hemisection in the nonhuman primate. Population curves on recovery of function were similar across the different tasks; in general, the population recovers to about 50% of baseline performance on measures of forelimb function. The behavioral outc...Continue Reading

References

Feb 1, 1987·Physical Therapy·R W Bohannon, M B Smith
May 1, 1974·Journal of the Experimental Analysis of Behavior·M N Branch, L R Gollub
Jan 1, 1971·Experimental Brain Research·C J VierckJ I Thornby
Jan 1, 1993·Experimental Brain Research·D S GlendinningB Y Cooper
Oct 6, 2000·Journal of the Neurological Sciences·R Suresh BabuA Namasivayam
Jun 4, 2004·Journal of Neurophysiology·Shigeto SasakiYukari Ohki
Jan 14, 2005·Journal of Neurophysiology·Grégoire CourtineV Reggie Edgerton
Jan 28, 2005·Journal of Neurotrauma·Kim D Anderson
Dec 21, 2006·Spinal Cord·J D SteevesUNKNOWN International Campaign for Cures of Spinal Cord Injury Paralysis
Jan 7, 2009·The Journal of Comparative Neurology·Ephron S RosenzweigMark H Tuszynski
Jan 22, 2009·Brain : a Journal of Neurology·Yukio NishimuraTadashi Isa
Jul 28, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·John H BrockMark H Tuszynski
Nov 16, 2010·Nature Neuroscience·Ephron S RosenzweigMark H Tuszynski
Dec 21, 2010·Experimental Brain Research·Devin L JindrichV Reggie Edgerton

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Citations

Dec 31, 2011·Translational Stroke Research·Adam R FergusonJessica L Nielson
Mar 20, 2012·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Yvette S NoutMark H Tuszynski
Aug 1, 2014·Journal of Neurotrauma·Jessica L NielsonAdam R Ferguson
Feb 16, 2016·Experimental Neurology·Zhengwen MaChristopher B Shields
Mar 26, 2014·Expert Opinion on Biological Therapy·Vidyasagar Devaprasad DedeepiyaSamuel J K Abraham
Jan 21, 2016·Journal of Neurotrauma·Ernesto A SalegioMichael S Beattie
Oct 2, 2012·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Ping FangMelitta Schachner
Sep 24, 2014·Behavioural Brain Research·Mitsuaki TakemiJunichi Ushiba
May 27, 2014·Frontiers in Systems Neuroscience·Hui-Xin QiJamie L Reed
Oct 13, 2016·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Marcus OhlssonLeif A Havton
Jun 15, 2016·Equine Veterinary Journal·Y S Nout-LomasH M Greene
Feb 27, 2018·Nature Medicine·Ephron S RosenzweigMark H Tuszynski
Oct 7, 2014·JMIR Rehabilitation and Assistive Technologies·Luis Vicente CalderitaAntonio Bandera
Nov 1, 2018·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·S WilsonM A Howard
Jun 27, 2019·Nature Neuroscience·Ephron S RosenzweigMark H Tuszynski
Nov 8, 2017·Stem Cells International·Woon Ryoung KimDongho Geum
Sep 1, 2021·Disease Models & Mechanisms·Mark ZüchnerJean-Luc Boulland

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