Methods for investigating age differences in the effects of prolonged exposures

American Journal of Industrial Medicine
D B Richardson, S Wing

Abstract

People experience physiological changes with age which may lead to changes in sensitivity to many kinds of exposure. In situations of prolonged, low level exposure, differences in the effects of exposures received at different ages may be difficult to evaluate, since study members receive low level exposures over a range of ages. Such investigations require examination of the effects of different age-patterns of exposure. Three approaches to investigating age-related variability in the effects of prolonged exposures are described: subcohort analyses; the use of smooth weighting functions; and the evaluation of separate effects of cumulative exposures received at different age ranges. Each method can contribute to the overall evaluation of age-specific exposure effects. These methods are illustrated with occupational cohort data for employees of Oak Ridge National Laboratory. The methods presented in this paper should facilitate examination of the effects of aging on sensitivity to prolonged exposures.

Citations

Apr 5, 2003·Environmental Health Perspectives·Christina C LawsonMichael Shelby
Jun 18, 2005·Occupational and Environmental Medicine·S Wing, D B Richardson
Mar 13, 2008·Environmental Health Perspectives·David B Richardson
Mar 3, 2011·Environmental Health Perspectives·Brisa Ney SánchezMartha Maria Téllez-Rojo
Jul 6, 2004·American Journal of Epidemiology·Shannon C BrownA James Ruttenber
Jan 9, 2007·New Solutions : a Journal of Environmental and Occupational Health Policy : NS·S WingA Stewart
Jan 30, 2004·American Journal of Industrial Medicine·Steve WingGary Mihlan
Oct 2, 2007·Cancer Causes & Control : CCC·David B RichardsonWolfgang Hoffmann

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