PMID: 7539308Apr 1, 1995Paper

Methods for studying neurotransmitter transduction mechanisms

Journal of Pharmacological and Toxicological Methods
P A Smith

Abstract

This review describes the methodologies used to study the transduction mechanisms that are activated in excitable cells by G-protein-coupled agonists. In view of the complexity of second-messenger systems, it is no longer relevant to ask, "What is the transduction mechanism involved in the action of a given neuromodulator?" because, in many cases, a variety of transduction mechanisms and physiological responses are invoked following receptor activation. This means that a single aspect of the physiological response must be selected for study in order to address the question of transduction mechanism. This review is therefore concerned with a description the use of patch- and voltage-clamp procedures to study transduction mechanism because they are designed to isolate one aspect of the physiological response: the change in activity of a single type of membrane ion channel.

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Citations

Jan 25, 2008·Journal of Neurophysiology·Christopher P FordPeter A Smith

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