Methods for the assessment of the effects of drugs on coronary blood flow in man

British Journal of Clinical Pharmacology
R H Swanton, D J Coltart

Abstract

The methods currently available for measurement of coronary blood flow in man are reviewed and their advantages and limitations discussed. Most of the techniques are invasive and involve cardiac catheterization. The least invasive isotope techniques are either not quantitative or involve expensive equipment not available in many centres. Two of the most suitable methods for assessing the effects of drugs on coronary flow are coronary sinus thermodilution and isotope washout curves using 133xenon or [125I]-iodo-antipyrine. The ideal technique for measuring coronary blood flow has yet to be developed.

References

Nov 1, 1977·Progress in Cardiovascular Diseases·E S WeissM M Ter-Pogossian
Jan 1, 1977·Catheterization and Cardiovascular Diagnosis·K ChatterjeeH J Swan
Jul 1, 1977·Progress in Cardiovascular Diseases·M A HeymannA M Rudolph
Sep 1, 1977·Progress in Cardiovascular Diseases·B L Zaret
Jan 1, 1976·Catheterization and Cardiovascular Diagnosis·W V ViewegA D Hagan
Feb 1, 1975·The American Journal of Cardiology·N I LevensonL S August
Mar 1, 1975·British Heart Journal·R Emanuel
Jan 1, 1975·Catheterization and Cardiovascular Diagnosis·H L Page
Jan 1, 1975·Catheterization and Cardiovascular Diagnosis·F J Klocke
Sep 1, 1967·Journal of the Tennessee Medical Association·G D Copeland
Jan 1, 1972·The American Journal of Cardiology·R J BingK Hellberg
Oct 1, 1972·Journal of Dairy Science·P J Wangsness, A D McGilliard
Jan 1, 1971·British Heart Journal·R Gorlin
Nov 1, 1971·Progress in Cardiovascular Diseases·W Schaper
Jan 1, 1971·American Heart Journal·A BenchimolJ L Gartlan
Mar 1, 1971·British Heart Journal·R S Ross
May 1, 1972·Circulation Research·D G Spiker, C W Smith
Oct 1, 1971·Journal of Applied Physiology·G D BuckbergD E Fixler
Dec 1, 1969·The American Journal of Cardiology·F J Klocke, S M Wittenberg
Nov 1, 1970·Circulation·C R ContiR S Ross
Mar 1, 1971·The American Journal of Cardiology·J S ForresterR Gorlin
Jan 1, 1968·British Heart Journal·W B Hood

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Citations

Mar 1, 1991·Clinical and Experimental Pharmacology & Physiology·M A ReidC F McLean
Jul 1, 1983·Journal of Biomedical Engineering·R HaywardH Swanton
Jan 1, 1983·British Journal of Clinical Pharmacology·R HaywardJ Hamer
Jul 20, 2007·Acta Anaesthesiologica Scandinavica·T Fuchs-BuderUNKNOWN 8th International Neuromuscular Meeting
Jul 10, 2012·Toxicology and Industrial Health·Xiufang ZhangBosheng Zhao

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