Methods for the determination of skeletal muscle blood flow: development, strengths and limitations

European Journal of Applied Physiology
Lasse GliemannYlva Hellsten

Abstract

Since the first measurements of limb blood flow at rest and during nerve stimulation were conducted in the late 1800s, a number of methods have been developed for the determination of limb and skeletal muscle blood flow in humans. The methods, which have been applied in the study of aspects such as blood flow regulation, oxygen uptake and metabolism, differ in terms of strengths and degree of limitations but most have advantages for specific settings. The purpose of this review is to describe the origin and the basic principles of the methods, important aspects and requirements of the procedures. One of the earliest methods, venous occlusion plethysmography, is a noninvasive method which still is extensively used and which provides similar values as other more direct blood flow methods such as ultrasound Doppler. The constant infusion thermodilution method remains the most appropriate for the determination of blood flow during maximal exercise. For resting blood flow and light-to-moderate exercise, the non-invasive ultrasound Doppler methodology, if handled by a skilled operator, is recommendable. Positron emission tomography with radiolabeled water is an advanced method which requires highly sophisticated equipment and allows ...Continue Reading

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Citations

Aug 4, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Emily C DunfordMaureen J MacDonald
Dec 31, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Jacqueline K LimbergJaume Padilla
Feb 29, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Danielle Jin-Kwang KimLawrence Sinoway
Jun 5, 2019·Journal of Cardiovascular Imaging·TheAnh Nguyen, Brian P Davidson
Jul 17, 2019·BioMed Research International·Wenfen LiuJiachun Li
Jul 6, 2019·Frontiers in Physiology·Keiichi YamaguchiKazushige Goto
Jan 9, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Benjamin E YoungPaul J Fadel
Mar 29, 2021·European Journal of Clinical Investigation·Marieta P TheodorakopoulouPantelis Sarafidis
Apr 21, 2021·Expert Review of Respiratory Medicine·Marieta P TheodorakopoulouAfroditi K Boutou
Jun 24, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Elizabeth J PekasSong-Young Park
Jun 15, 2021·Respiratory Physiology & Neurobiology·Shane M HammerCarl J Ade

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