Methods in safety pharmacology in focus

Journal of Pharmacological and Toxicological Methods
Michael K PugsleyMichael J Curtis

Abstract

This focused issue of the Journal of Pharmacological and Toxicological Methods is the fifth to highlight Methods in Safety Pharmacology and includes a number of articles from the 7th Annual Safety Pharmacology Society (SPS) meeting that was held in Edinburgh, Scotland, September 19-21, 2007. However, unlike issues of the past, in which content predominantly focused on cardiovascular issues (specifically QT interval prolongation, QT-HR correction methods and validation of non-clinical cardiovascular models) this issue is composed of a number of non-cardiovascular methods papers and review articles. Of particular interest to readers will be articles related to CNS studies, in particular neurobehavioral assessments in non-human primates and the effects of drugs in juvenile and adult rats (an article that may be relevant in light of recent EU/US pediatric legislation). While cardiovascular function may not dominate there are several useful methodological papers including an assessment of cardiovascular sensitivity of drugs in conscious and anesthetized non-human primates, and a mathematical model (fractal analysis) applied to canine heartbeat dynamics. A first for the journal is a paper by Vargas et al., (2008-this issue) in which ...Continue Reading

References

May 8, 2001·Trends in Pharmacological Sciences·J I VandenbergT J Campbell
Mar 19, 2003·Circulation·David J MilanCalum A MacRae
Feb 21, 2006·American Journal of Physiology. Heart and Circulatory Physiology·David J MilanCalum A MacRae
Jun 8, 2007·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Richard L MaydenShunping He
Feb 23, 2008·Journal of Pharmacological and Toxicological Methods·S W MittelstadtJ R Hove
Jul 1, 2008·Journal of Pharmacological and Toxicological Methods·Jean-Pierre Valentin, Tim Hammond
Jul 1, 2008·Journal of Pharmacological and Toxicological Methods·David V Gauvin, Theodore J Baird
Jul 8, 2008·Journal of Pharmacological and Toxicological Methods·William S RedfernJean-Pierre Valentin
Jul 16, 2008·Journal of Pharmacological and Toxicological Methods·Dingzhou LiDerek J Leishman
Aug 12, 2008·Journal of Pharmacological and Toxicological Methods·Silvana LindgrenMichael K Pugsley

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Citations

Feb 8, 2014·Neurotoxicology and Teratology·Jian-Hui HeChun-Qi Li
Apr 17, 2009·Expert Opinion on Drug Metabolism & Toxicology·Peter M Eimon, Amy L Rubinstein
May 21, 2013·Journal of Pharmacological and Toxicological Methods·Simon AuthierMichael K Pugsley
Sep 15, 2017·The Journal of Toxicological Sciences·Vudhiporn LimprasutrRobert L Hamlin

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