PMID: 9174260Apr 11, 1997Paper

Methods of analysis of chiral non-steroidal anti-inflammatory drugs

Journal of Chromatography. B, Biomedical Sciences and Applications
N M Davies

Abstract

Although the analysis of the enantiomers of chiral non-steroidal anti-inflammatory drugs (NSAIDs) has been carried out for over 20 years, there often remains a deficit within the pharmaceutical and medical sciences to address this issue. Hence, despite world-wide therapeutic use of chiral NSAIDs the importance of stereoselectivity in pharmacokinetic, pharmacodynamic and pharmacological activity and disposition has often been ignored. This review presents both the general principles that allow separation of chiral NSAID enantiomers, and discusses both the advantages and disadvantages of the available chromatographic assay methods and procedures used to separately quantify NSAID enantiomers in biological matrices.

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Citations

Oct 6, 2004·Archives of Pharmacal Research·Man-Jeong Paik, Kyoung-Rae Kim
Apr 6, 2004·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Man-Jeong PaikKyoung-Rae Kim
May 23, 2001·Clinical Pharmacokinetics·M J BarbanojI Gich
Feb 10, 2000·The American Journal of Pathology·K S ChappleM A Hull
Oct 23, 2004·Drug Metabolism and Pharmacokinetics·Hiroyuki TsudaMalcolm A Moore
Feb 9, 2002·Biopharmaceutics & Drug Disposition·G Gübitz, M G Schmid

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