Methods to Compare Adverse Events in Twitter to FAERS, Drug Information Databases, and Systematic Reviews: Proof of Concept with Adalimumab.

Drug Safety : an International Journal of Medical Toxicology and Drug Experience
Karen SmithGraciela Gonzalez-Hernandez

Abstract

Adverse drug reactions (ADRs) are associated with significant health-related and financial burden, and multiple sources are currently utilized to actively discover them. Social media has been proposed as a potential resource for monitoring ADRs, but drug-specific analytical studies comparing social media with other sources are scarce. Our objective was to develop methods to compare ADRs mentioned in social media with those in traditional sources: the US FDA Adverse Event Reporting System (FAERS), drug information databases (DIDs), and systematic reviews. A total of 10,188 tweets mentioning adalimumab collected between June 2014 and August 2016 were included. ADRs in the corpus were extracted semi-automatically and manually mapped to standardized concepts in the Unified Medical Language System. ADRs were grouped into 16 biologic categories for comparisons. Frequencies, relative frequencies, disproportionality analyses, and rank ordering were used as metrics. There was moderate agreement between ADRs in social media and traditional sources. "Local and injection site reactions" was the top ADR in Twitter, DIDs, and systematic reviews by frequency, ranked frequency, and index ranking. The next highest ADR in Twitter-fatigue-ranked ...Continue Reading

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Citations

May 10, 2019·Pediatric Blood & Cancer·Charles A PhillipsRaina M Merchant
Nov 9, 2019·Journal of Medical Internet Research·Jill S BorchertKirk E Dineley
Nov 28, 2019·Journal of Health and Social Behavior·Kristin Kay Barker
Oct 2, 2020·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Su GolderGraciela Gonzalez-Hernandez
Jun 20, 2020·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Bissan AudehCédric Bousquet

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Software Mentioned

FAERS
ADRMine
Humira
MetaMap
Lexicomp
Opened API
UMLS
Micromedex

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