Abstract
We used various methods for identifying and prioritizing patient-centered outcomes (PCOs) for comparative effectiveness research (CER). We considered potential PCOs ("benefits" and "harms") related to (1) gabapentin for neuropathic pain and (2) quetiapine for bipolar depression. Part 1 (April 2014 to March 2015): we searched for PCO research and core outcome sets (COSs). We conducted electronic searches of bibliographic databases and key websites and examined FDA prescribing information and reports of clinical trials and systematic reviews. We asked patient and clinician co-investigators to identify PCOs. Part 2 (not part of our original study protocol): in 2015, we surveyed members of The TMJ Association, Ltd., a patient group associated with temporomandibular disorders (4130 invitations sent). Participants prioritized (1) the importance of six potential benefits and (2) 21 potential harms selected by the investigators in part 1, using stated preference methods. We calculated descriptive statistics. In part 1, we identified a COS for pain, the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) recommendations. The COS identified several important benefits, but it lacked specific recommendation...Continue Reading
References
Mar 7, 2001·BMJ : British Medical Journal·B HanleyI Chalmers
Aug 2, 2002·Journal of Women's Health & Gender-based Medicine·Yvonne AndejeskiIrene M Rich
Dec 9, 2003·Pain·Dennis C TurkJames Witter
Dec 29, 2004·Pain·Robert H DworkinUNKNOWN IMMPACT
Jul 21, 2006·The Cochrane Database of Systematic Reviews·E S NilsenA D Oxman
Oct 17, 2007·Pain·Dennis C TurkBob A Rappaport
Apr 14, 2010·Archives of Internal Medicine·Surrey M WaltonRandall S Stafford
Feb 18, 2011·Health Expectations : an International Journal of Public Participation in Health Care and Health Policy·Rosemary BarberSarah Cook
Mar 4, 2011·The New England Journal of Medicine·Deborah A ZarinNicholas C Ide
Jan 26, 2012·The Patient·Jordan J Louviere, Terry N Flynn
May 18, 2012·The Cochrane Database of Systematic Reviews·Paula Williamson, Mike Clarke
Aug 8, 2012·Trials·Paula R WilliamsonPeter Tugwell
May 3, 2013·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Rachael L Fleurence, David O Meltzer
Jun 5, 2013·Health Expectations : an International Journal of Public Participation in Health Care and Health Policy·Nathan D ShippeeM Hassan Murad
Sep 1, 2012·Journal of Comparative Effectiveness Research·Jonathan BooteAnthea Sutton
Feb 27, 2014·BMC Health Services Research·Juan Pablo DomecqMohammad Hassan Murad
Apr 29, 2014·The Cochrane Database of Systematic Reviews·R Andrew MooreAndrew S C Rice
Jul 17, 2014·Drug Design, Development and Therapy·Sirijit SuttajitBenchalak Maneeton
Nov 4, 2015·Systematic Reviews·Evan Mayo-WilsonKay Dickersin
Nov 13, 2015·Trials·Elizabeth GargonMike Clarke
Jan 20, 2016·PloS One·Sarah L GorstPaula R Williamson
Apr 6, 2016·Health Affairs·Bara Vaida
Sep 2, 2016·The Patient·Peter J Pitts
May 23, 2017·Journal of Clinical Epidemiology·Evan Mayo-WilsonUNKNOWN MUDS investigators
Aug 27, 2017·Journal of Clinical Epidemiology·Evan Mayo-WilsonKay Dickersin