Methohexital vs midazolam/flumazenil anaesthesia during laryngoscopy under jet ventilation

Acta Anaesthesiologica Scandinavica. Supplementum
P J KulkaC Apffelstaedt

Abstract

In a randomised clinical study, two total intravenous anaesthesia techniques for microlaryngoscopic laser surgery were compared. After an induction dose of 100 mg methohexital, Group I received a maintenance infusion of 10 mg.min-1. In Group II anaesthesia was obtained by 15 mg midazolam followed by 0.1 mg.min-1 continuously and terminated by the injection of flumazenil. For analgesia 5 mg alfentanil were administered. Opiate-induced respiratory depression was antagonised by 0.08 to 0.12 mg naloxone. Prior to, during, and after surgery, adrenergic response was assessed by HPLC-analysis of blood taken from a peripheral vein. Haemodynamic responses to the operation and during the post-operative period were almost identical in both groups. In Group I, the mean recovery period of 14 min was significantly longer than in Group II (9 min), where patients received a mean dose of 0.53 mg (+/- 0.15) flumazenil. Resedation could be observed in all patients receiving flumazenil within 60 min after antagonisation, which was associated with a mean decrease in O2-saturation from 95% to 88%. There was no difference in epinephrine and norepinephrine blood levels between the two groups prior to and during anaesthesia. In all patients, arousal wa...Continue Reading

References

Jan 1, 1990·Acta Anaesthesiologica Scandinavica. Supplementum·N D CroughwellD K Goodman
Jan 1, 1987·The Annals of Otology, Rhinology, and Laryngology·G S GussackE J Tacchi
May 1, 1987·Anaesthesia·I D ConacherG N Morritt
Mar 1, 1988·Clinical Pharmacology and Therapeutics·M P PerssonP Hartvig
Mar 1, 1985·Anesthesiology·J G RevesD J Greenblatt
Apr 1, 1988·Anesthesia and Analgesia·C M Alexander, J B Gross
Apr 1, 1985·British Journal of Anaesthesia·I D ConacherG N Morritt
Oct 1, 1983·Acta Anaesthesiologica Scandinavica·J HovorkaI Kalli
Sep 1, 1984·Critical Care Medicine·P A Scheck, C Mallios
Sep 1, 1983·Anesthesiology·R J HudsonP G Burch
Dec 1, 1980·Anesthesiology·A ForsterM Gemperle

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Citations

Jul 3, 2013·Journal of Clinical Monitoring and Computing·Tod B SloanEvalina Burger
Jan 1, 1995·Acta Anaesthesiologica Scandinavica. Supplementum·J G Whitwam
Oct 23, 1997·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·C R Chudnofsky
Nov 1, 1993·Journal of Clinical Anesthesia·B K Philip
Aug 1, 1997·Anaesthesia and Intensive Care·W Rushatamukayanunt, T Tritrakarn

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