PMID: 3756057Sep 1, 1986Paper

Methohexitone anaesthesia for microlaryngoscopy: circulatory modulation with metoprolol and dihydralazine

British Journal of Anaesthesia
H MagnussonH G Sonander

Abstract

Anaesthesia for microlaryngoscopy was induced and maintained with fentanyl 3 micrograms kg-1 and methohexitone (initial bolus of 1-1.5 mg kg-1 plus subsequent infusion of 4 mg kg-1 h-1). Suxamethonium was used to induce neuromuscular blockade. Twenty minutes before induction of anaesthesia, previously normotensive patients (n = 35), and patients with hypertension well controlled by beta-receptor antagonists (n = 16) were pretreated with metoprolol (M) 0.2 mg kg-1 i.v. and dihydralazine (DH) 0.2 mg kg-1 i.v., dihydralazine 0.2 mg kg-1 i.v. alone, or saline. Arterial pressure (AP) and heart rate (HR) were monitored: any arrhythmia and ST60-T changes were noted. After the methohexitone infusion was stopped, the times for emergence and full recovery were short (median 2 min 15 s and 5 min later, respectively). Pretreatment with M + DH abolished increases in AP and HR during endoscopy. Arrhythmias were observed in fewer pretreated patients than in controls (P less than 0.05). ST60-T changes in the ECG indicating myocardial ischaemia were found in two of 19 M + DH and in six of 21 saline-pretreated patients. One of these six patients developed a myocardial infarction. Pretreatment with dihydralazine alone attenuated the pressor respo...Continue Reading

Citations

Dec 1, 1989·Clinical Otolaryngology and Allied Sciences·P M Robinson
Mar 5, 2010·Therapeutic Advances in Cardiovascular Disease·Fabio AngeliGianpaolo Reboldi
Jul 27, 2010·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Fabio AngeliGianpaolo Reboldi

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