Methotrexate ameliorates T cell dependent autoimmune arthritis and encephalomyelitis but not antibody induced or fibroblast induced arthritis

Annals of the Rheumatic Diseases
F LangeR Holmdahl

Abstract

To investigate the mode of action of methotrexate (MTX) in different types of models for rheumatoid arthritis (RA) and multiple sclerosis (MS). Models for RA and MS were selected known to have different pathogenesis--that is, fibroblast induced arthritis in SCID mice, collagen induced arthritis (CIA), anticollagen II antibody induced arthritis (CAIA), and experimental autoimmune encephalomyelitis (EAE) in (Balb/c x B10.Q)F1 and B10.Q mice, and Pristane induced arthritis in DA rats (PIA). The MTX treatment was started 1 day after the onset of disease and continued for 14 days to compare effects on the different models. All models known to be critically dependent on T cell activation (CIA, PIA, and EAE) were effectively down regulated by titrated doses of MTX. In contrast, no effects were seen on fibroblast induced arthritis or CAIA. No effects were seen on the levels of anticollagen II antibodies in the CIA experiment. The data show that MTX has strong ameliorative effect on both classical models of RA, like CIA and PIA, but also on a model for MS, EAE. It also suggests that MTX operates only in diseases which are preceded by, and dependent on, T cell activation. A comparison of CAIA and CIA suggested that MTX operates independe...Continue Reading

References

Dec 1, 1990·Immunological Reviews·R HolmdahlJ A Mo
Apr 1, 1989·Arthritis and Rheumatism·R SegalB Tartakovsky
Aug 1, 1983·The Journal of Experimental Medicine·J M Stuart, F J Dixon
Sep 12, 1995·Proceedings of the National Academy of Sciences of the United States of America·Y WangL A Matis
Mar 1, 1997·Clinical and Experimental Immunology·A MüssenerL Klareskog
Mar 1, 1997·Clinical and Experimental Immunology·L Marinova-MutafchievaR N Maini
Apr 7, 1998·Clinical and Experimental Immunology·L SvenssonL Jansson
May 3, 2000·The Journal of Experimental Medicine·S KleinauB Heyman
Dec 4, 2002·Nature Genetics·Peter OlofssonRikard Holmdahl
May 31, 2003·Nature Reviews. Drug Discovery·Josef S Smolen, Günter Steiner

❮ Previous
Next ❯

Citations

Jan 23, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Lars KlareskogLars Alfredsson
Jan 27, 2007·Arthritis Research & Therapy·Kutty Selva Nandakumar, Rikard Holmdahl
Apr 14, 2010·Molecular Medicine·Hanna SchierbeckHelena Erlandsson Harris
Nov 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Christine BeetonK George Chandy
Jan 16, 2016·Immunopharmacology and Immunotoxicology·Samra Sardar, Åsa Andersson
Nov 28, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Qing-Tong WangWei Wei
Jun 19, 2010·Progress in Neurobiology·Eilhard MixUwe K Zettl
Sep 17, 2008·The International Journal of Biochemistry & Cell Biology·Liselotte BäckdahlStephan Beck
Dec 25, 2007·Pharmacology & Therapeutics·Daniel TraceyPaul P Tak
Mar 4, 2014·Chinese Journal of Integrative Medicine·Roba M TalaatKarima I El-Dosoky
Oct 13, 2006·Scandinavian Journal of Immunology·F LangeU Sack
Jan 3, 2013·Annals of the New York Academy of Sciences·Mamatha PasnoorUNKNOWN Muscle Study Group
Mar 31, 2015·Annals of the Rheumatic Diseases·Clara DeesJörg H W Distler
Jan 5, 2011·Journal of Zhejiang University. Science. B·Wei-kun HouShe-min Lu
Apr 4, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Qian DingYuhong Xu
Sep 15, 2017·International Journal of Molecular Sciences·Seulgi ChoiJae-Hwan Nam
Mar 1, 2008·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·C TreeseU Sack
Jul 7, 2009·The Journal of Veterinary Medical Science·Toshiaki NagateJun Nakayama
Aug 3, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Marjolein M J CaronAdhiambo M A Witlox
Jun 1, 2019·Scientific Reports·Paul M LübckeBrigitte Müller-Hilke
May 16, 2018·Journal of Cellular Physiology·Zhenzhou LiuMei Liu
Apr 6, 2019·European Journal of Pharmacology·Rakesh K SinghRyan S Funk
Jun 3, 2018·Journal of Controlled Release : Official Journal of the Controlled Release Society·Abdulaziz M AldayelZhengrong Cui
Jun 15, 2021·Clinical and Translational Science·Zachary L TaylorLaura B Ramsey

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.