PMID: 8598972Mar 1, 1996Paper

Methotrexate and misoprostol when surgical abortion fails

Obstetrics and Gynecology
E A SchaffP Franks

Abstract

To describe the use of methotrexate and misoprostol to induce abortion in pregnancies up to 8 weeks when uterine or cervical anomalies make suction curettage difficult or impossible. Four consecutive women, 8 weeks pregnant or less and with failed suction curettage, were given methotrexate 50 mg per square meter intramuscularly followed by a misoprostol 800-microgram suppository 72 hours later. A repeat dose of a misoprostol 800-microgram vaginal suppository was administered on day 4 if there was no bleeding, and an additional dose was given if the repeat beta-hCG titer had not decreased by at least 50%. Subjects were followed-up with serum or urine hCG assays. Complete abortion was defined by vaginal bleeding and a negative urine pregnancy test. Subjects completed a daily symptom log and a satisfaction questionnaire when the abortion was complete. The four women referred after failed suction curettage had the following anatomic problems: a uterus bicornis bicollis, a bicornuate uterus, uterine leiomyomas, and cervical stenosis resulting from previous laser surgery. All subjects had a complete abortion from methotrexate and misoprostol. Mild gastrointestinal side effects were reported by all four subjects: nausea (two subjects)...Continue Reading

References

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Citations

May 1, 1997·Obstetrics and Gynecology·D A Grimes
Oct 6, 1997·Clinics in Dermatology·S SaidG D Weinstein
Mar 30, 2000·The New England Journal of Medicine·S Christin-MaitreI M Spitz
Nov 16, 2010·Contraception·Ericka Gibson, Courtney A Schreiber
Feb 17, 2007·Contraception·Gweneth B LazenbyNicholas S Fogelson
Jun 30, 2004·The Journal of Family Planning and Reproductive Health Care·Fiona C New, Claire K Candelier
Jun 30, 2004·The Journal of Family Planning and Reproductive Health Care·Helen Bradshaw, Peter Stewart
Jan 22, 2009·Obstetrics and Gynecology·Lynn BorgattaPhillip G Stubblefield
Jul 28, 2006·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·David M ShererOvadia Abulafia
Nov 4, 2017·Case Reports in Obstetrics and Gynecology·Michael Saad-NaguibUsha Verma

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