Methotrexate for alopecia areata: A systematic review and meta-analysis

Journal of the American Academy of Dermatology
Kevin PhanDeshan Frank Sebaratnam

Abstract

Methotrexate has been used both as monotherapy and as an adjunct to corticosteroids in the treatment of alopecia areata (AA), though there exists a paucity of definitive evidence and guidelines in this setting. To 1) determine the efficacy and risks associated with methotrexate therapy for AA, 2) determine the differences in efficacy of combination (methotrexate plus corticosteroids) versus stand-alone (methotrexate) treatment, and 3) determine the relative efficacy of methotrexate in adult versus pediatric populations. A systematic review and meta-analysis was performed according to recommended PRISMA [Preferred Reporting Items for Systematic Reviews and Meta-Analyses] guidelines. Methotrexate has reasonable effectiveness in patients with severe AA; adults appear to be more responsive to methotrexate treatment than pediatric patients. Combination treatment results in a higher complete response rate than methotrexate stand-alone treatment. A large proportion of patients had recurrence in the setting of tapering treatment. Complication rates were acceptable and similar between adult and pediatric patients. The studies reviewed were retrospective observational studies with heterogeneity between centers in terms of methotrexate do...Continue Reading

Citations

Jan 29, 2019·Journal of Cutaneous Medicine and Surgery·Erika L CrowleyMelinda J Gooderham
Feb 15, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·K Phan, D F Sebaratnam
Aug 3, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·P MasciaA Taïeb
Jan 22, 2020·Experimental Dermatology·David Broadley, Kevin J McElwee
Apr 30, 2020·International Journal of Dermatology·Ghazal AhmedNeel Prabha
Dec 6, 2019·The Australasian Journal of Dermatology·Kevin PhanGayle Fischer
Apr 24, 2020·Drugs·Aunna Pourang, Natasha Atanaskova Mesinkovska
Oct 4, 2019·Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia·Alfredo RossiMaria C Fortuna
Mar 16, 2021·Journal of Cutaneous Medicine and Surgery·Misaki Kinoshita-IsePerla Lansang
Jun 21, 2020·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Xin JiangBing Zhao
May 12, 2021·Clinics in Dermatology·Nicole FaganDmitri Wall
Aug 18, 2021·Clinical Reviews in Allergy & Immunology·Cheng ZhouJianzhong Zhang
May 1, 2020·Current Pediatric Reviews·Rebecca AffordJoseph M Lam
Feb 9, 2020·Annales de dermatologie et de vénéréologie·E Delaporte
Jul 30, 2020·Recent Patents on Inflammation & Allergy Drug Discovery·Kam L HonSteven K F Loo
Jan 19, 2022·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Dimitra Aikaterini LintzeriUlrike Blume-Peytavi

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