Methotrexate in juvenile idiopathic arthritis: advice and recommendations from the MARAJIA expert consensus meeting

Pediatric Rheumatology Online Journal
Giovanna FerraraRheumatology Italian Study Group

Abstract

Conventional pharmacological therapies for the treatment of juvenile idiopathic arthritis (JIA) consist of non-biological, disease-modifying antirheumatic drugs, among which methotrexate (MTX) is the most commonly prescribed. However, there is a lack of consensus-based clinical and therapeutic recommendations for the use of MTX in the management of patients with JIA. Therefore, the Methotrexate Advice and RecommendAtions on Juvenile Idiopathic Arthritis (MARAJIA) Expert Meeting was convened to develop evidence-based recommendations for the use of MTX in the treatment of JIA. The preliminary executive committee identified a total of 9 key clinical issues according to the population, intervention, comparator, outcome (PICO) approach, and performed an evidence-based, systematic, literature review. During the subsequent Expert Meeting, the relevant evidence was assessed and graded, and 10 recommendations were made. Recommendations relating to the efficacy, optimal dosing and route of administration and duration of treatment with MTX in JIA, and to the issue of folic acid supplementation to prevent MTX side effects, use of MTX in the treatment of chronic JIA-associated uveitis, combination treatment with biologic agents, and the use...Continue Reading

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Citations

Mar 8, 2019·Current Opinion in Ophthalmology·Julie GueudryBahram Bodaghi
Feb 25, 2020·Arthritis & Rheumatology·Casper G SchoemakerSebastiaan J Vastert
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Jul 5, 2021·Clinical Rheumatology·Ummusen Kaya AkcaYelda Bilginer
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Methods Mentioned

BETA
contraception

Software Mentioned

PICO
PICO ( Population Intervention Comparator - Outcome )
MARAJIA

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