[Methotrexate in the therapy of juvenile idiopathic arthritis].

Zeitschrift für Rheumatologie
D HolzingerD Föll

Abstract

Treatment with low-dose methotrexate (MTX) is an important element in the therapy of juvenile idiopathic arthritis (JIA). It could be demonstrated in placebo-controlled trials that MTX is a safe and effective drug which is generally well tolerated by children and adolescents. MTX is usually used at a dose of 10-15 mg/m(2)/week, whereby oral administration is preferred for children. Side effects occur mainly in the form of gastro-intestinal discomfort such as nausea and vomiting or raised transaminases, which can be effectively treated with folic-acid supplementation.There are no general recommendations to date regarding in particular duration and discontinuation of MTX treatment or combination treatment with other disease-modifying antirheumatic drugs or biologics. These unresolved questions are the subject of current trials in which biomarkers have an increasingly important role.

References

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Citations

Aug 22, 2014·Pediatric Rheumatology Online Journal·Mohamed AlbarouniGerd Horneff
Nov 3, 2016·The Journal of Rheumatology·Sigrun R HofmannChristian M Hedrich

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