Methotrexate intoxication: Beyond the adverse events

International Journal of Rheumatic Diseases
Ediz DalkilicYavuz Pehlivan

Abstract

Methotrexate (MTX) is the first-line disease-modifying antirheumatic drug in rheumatoid arthritis (RA). However, this anchor may cause some side effects that may range from nausea to mortality. The clinical features of MTX toxicity are under-researched. In this study, we aimed to find out the potential predisposing factors and outcomes of the MTX toxicity (n = 31). The data were collected from 31 patients whose ages ranged from 25 to 81 years, who were suffering from immune-mediated inflammatory diseases and major MTX-related toxicity. Out of 31 patients, six (19.4%) used MTX every day, and 13 (41.9%) patients had renal insufficiency who were admitted to the hospital because of mucositis (90.3%) and fever (71%). While using MTX, 27 patients (87.1%) were discharged after the treatment and four patients (12.9%) died. Although MTX has high efficacy for the toxicity ratio, wrong use and dosage of MTX may be harmful to patients. Thus, patients should be informed about the proper use of MTX.

References

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Nov 26, 2009·European Journal of Clinical Pharmacology·Mao Mao AnYuan Ying Jiang
Aug 6, 2014·Nature Reviews. Rheumatology·Sabri Alsaeedi, Edward C Keystone
Mar 7, 2017·International Journal of Rheumatic Diseases·Sajal AjmaniVikas Agarwal

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Citations

Aug 28, 2020·Journal of Ophthalmology·Ge Wang, Xiaoyan Peng
Nov 13, 2020·British Journal of Clinical Pharmacology·Azzurra SchicchiCarlo A Locatelli
Feb 10, 2021·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·Eman Magdy, Shereen Ali

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