Methotrexate pharmacokinetics and effects in women receiving methotrexate 50 mg and 60 mg per square meter for early abortion

American Journal of Obstetrics and Gynecology
M D Creinin, M A Krohn

Abstract

Our goal was to evaluate the pharmacokinetics and safety of methotrexate in doses of 50 mg/m2 and 60 mg/m2 in regimens for early abortion. A randomized controlled trial was performed in women requesting an abortion at < or = 49 days' gestation. Twenty women were treated with intramuscular methotrexate 50 mg/m2 (group 1) or 60 mg/m2 (group 2). Methotrexate levels were determined serially for the first 24 hours, then every 24 hours for 7 days. On the seventh day misoprostol 800 microg was administered vaginally. The misoprostol dose was repeated 24 hours later if abortion did not occur. Complete abortion occurred in 9 of 10 (90%, 95% confidence interval 56% to 100%) patients in group 1 and all 10 (100%, 95% confidence interval 69% to 100%; p = 0.99) in group 2. Methotrexate levels peaked within 1 to 2 hours and were nondetectable within 48 hours in all patients in group 1 and 72 hours in group 2. Both the maximum concentration of methotrexate and the area under the curve were significantly greater for group 2. Methotrexate clearance rates were 7.89 +/- 1.98 L/hr and 5.55 +/- 0.83 L/hr (p = 0.003), respectively. The serum levels of intramuscular methotrexate with 50 mg/m2 and 60 mg/m2 regimens indicate that these are safe treatmen...Continue Reading

References

Nov 1, 1995·American Journal of Obstetrics and Gynecology·M D CreininC Klaisle
Oct 1, 1993·Contraception·M D Creinin, P D Darney
Jun 1, 1993·American Journal of Obstetrics and Gynecology·T G Stovall, F W Ling
Apr 1, 1996·Therapeutic Drug Monitoring·L EdnoB Combe

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Citations

Apr 4, 2000·Contraception·J G KahnM D Creinin
Jan 16, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Stuart M LichtmanMatti Aapro
Oct 20, 2012·Journal of Medical Primatology·Elizabeth MicksJeffrey Jensen
Jan 23, 1999·American Journal of Obstetrics and Gynecology·M D Creinin, H Jerald
Jun 18, 2002·American Journal of Obstetrics and Gynecology·Gary H LipscombFrank W Ling
Aug 16, 2000·American Journal of Obstetrics and Gynecology·H C Pymar, M D Creinin
Sep 4, 2016·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Judith A SoonEdith Guilbert
Feb 11, 2015·Journal de gynécologie, obstétrique et biologie de la reproduction·L LagarceP Lainé-Cessac
Jan 19, 2012·Expert Opinion on Drug Delivery·Zulfequar Ahamad KhanBrahmeshwar Mishra
Nov 11, 2011·The Cochrane Database of Systematic Reviews·Regina KulierAldo Campana
Nov 10, 2020·Gynécologie, Obstétrique, Fertilité & Sénologie·E Elefant
May 10, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sara Mohamed Naguib Abdel HafezFatma Alzhraa Fouad Abdelbaky

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