Methotrexate polyglutamate concentrations are not associated with disease control in rheumatoid arthritis patients receiving long-term methotrexate therapy

Arthritis and Rheumatism
L K StampMurray L Barclay

Abstract

There are limited data suggesting that methotrexate polyglutamate (MTXGlu) concentrations can guide MTX dosing in patients with rheumatoid arthritis (RA). The aim of this study was to define a therapeutic range of red blood cell (RBC) MTXGlu(n) concentrations (where n refers to the number of glutamate groups), including threshold values for efficacy and adverse effects in patients receiving long-term oral MTX treatment. A cross-sectional study of 192 patients receiving oral MTX was undertaken. Disease activity was assessed by the swollen and tender joint counts, the C-reactive protein level, and the Disease Activity Score in 28 joints (DAS28). High disease activity was defined as a DAS28 of >3.2. A standardized questionnaire regarding common MTX adverse effects was completed. The MTX dosage was significantly higher in patients in whom the swollen joint count and DAS28 were higher. The MTXGlu(4), MTXGlu(5), MTXGlu(3-5), and MTXGlu(1-5) concentrations were significantly higher in patients with high disease activity. After correction for age, the estimated glomerular filtration rate, and the MTX dosage, the association remained significant for MTXGlu(5). RBC folate concentrations were significantly higher in the group with high di...Continue Reading

References

Jul 1, 1991·Annals of the Rheumatic Diseases·M J AhernP D Hall
Oct 1, 1987·Biochemical Pharmacology·J JolivetM F Pinard
Oct 1, 1989·British Journal of Rheumatology·M TishlerM Yaron
Aug 1, 1993·British Journal of Rheumatology·P Seideman
Oct 20, 1998·Arthritis and Rheumatism·A M van GestelP L van Riel
Sep 28, 2007·Therapeutic Drug Monitoring·Alenka J BrooksMurray L Barclay
Apr 4, 2008·Pharmacogenomics·Prabha Ranganathan
Nov 1, 2008·Arthritis and Rheumatism·Judith M DalrympleMurray L Barclay
Oct 17, 2009·Collegian : Journal of the Royal College of Nursing, Australia·Jill White

❮ Previous
Next ❯

Citations

Jan 27, 2011·Zeitschrift für Rheumatologie·C Fiehn
Jul 29, 2010·Current Rheumatology Reports·Maria I DanilaS Louis Bridges
Jul 31, 2012·International Journal of Rheumatology·Karina I HalilovaMaria I Danila
Jun 12, 2012·Arthritis Research & Therapy·Lisa K StampPaul A Hessian
Nov 8, 2013·Rheumatology·Lisa K Stamp, Murray Barclay
May 27, 2014·Expert Review of Clinical Immunology·Maja Bulatović Ćalasan, Nico M Wulffraat
Jul 31, 2013·Arthritis and Rheumatism·Marjolein BlitsCornelis L Verweij
Mar 5, 2013·Biopharmaceutics & Drug Disposition·Dong-Yang LiuWilliam J Jusko
Nov 30, 2013·Annals of the Rheumatic Diseases·Maja Bulatović ĆalasanNico M Wulffraat
Dec 4, 2013·Annals of the Rheumatic Diseases·Maurits C F J de RotteRobert de Jonge
Jun 9, 2016·Clinical Pharmacology in Drug Development·Monika FischerHala M Fadda
Apr 7, 2011·Thérapie·Marie-Clémence VerdierDanièle Bentué-Ferrer
Nov 5, 2016·Nature Reviews. Rheumatology·Philip M BrownJohn D Isaacs
Jul 17, 2013·The Journal of Rheumatology·Lisa K StampPaul A Hessian
Jul 19, 2014·World Journal of Orthopedics·Megan L Krause, Eric L Matteson
Jul 13, 2018·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Lisa K StampPeter T Chapman
May 26, 2018·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Souhir ChaabaneAbdellatif Maalej
Dec 14, 2011·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Varun Dhir, Amita Aggarwal
Mar 12, 2020·Nature Reviews. Rheumatology·Jose U ScherSteven B Abramson
Apr 6, 2019·European Journal of Pharmacology·Rakesh K SinghRyan S Funk

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.