Methotrexate Reduces DNA Integrity in Sperm From Men With Inflammatory Bowel Disease

Gastroenterology
Dana LeySumona Saha

Abstract

There are few data on the effects of methotrexate on reproductive capacity in men with inflammatory bowel diseases (IBDs). We performed a case-control study to determine the effects of methotrexate on sperm quality and genetic integrity. We compared sperm samples from 7 men with IBD who had been exposed to methotrexate for at least 3 months with sperm samples collected from 1912 age-matched men at fertility centers (controls) where sperm parameters would be expected to be worse than those of the general population. Sperm were evaluated by basic semen analysis and advanced sperm integrity testing. In samples from men with IBD, all basic semen analysis parameters were within normal limits. However, these samples had reduced sperm integrity, based on significant increases in levels of DNA fragmentation and damage from oxidative stress compared with controls. Our findings indicate that methotrexate can reduce DNA integrity in sperm and cause damage via oxidative stress.

Citations

Jun 20, 2018·Journal of Crohn's & Colitis·Anne GrosenJens Kelsen
Aug 20, 2019·Basic & Clinical Pharmacology & Toxicology·Suping XiongXiaoning Zhang
Sep 10, 2020·Nature Reviews. Gastroenterology & Hepatology·Wendy A GoodmanTheresa T Pizarro
Apr 1, 2019·The World Journal of Men's Health·Yong Eun Park, Tae Oh Kim
Jan 8, 2021·Expert Opinion on Drug Safety·Robyn LaubeRupert W Leong
May 1, 2021·Journal of Clinical Medicine·Artur WdowiakRafał Filip
May 14, 2021·Expert Review of Clinical Pharmacology·Rebecca Fischer-Betz, Monika Østensen
May 29, 2021·Therapeutic Advances in Gastroenterology·Robyn LaubeRupert W Leong
Sep 1, 2021·Inflammatory Bowel Diseases·Anne GrosenStephen B Hanauer

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