PMID: 9175024Jan 1, 1997Paper

Methotrexate use in systemic lupus erythematosus

Lupus
Y KipenE F Morand

Abstract

Low dose pulse oral methotrexate (MTX) is a well established treatment for rheumatoid arthritis, and short term open studies have suggested beneficial effects of MTX in SLE. This study was designed to investigate MTX treatment maintenance rates in SLE using life table analysis, and to determine whether MTX use was associated with a dose reduction of concomitant steroid therapy. All SLE patients managed by physicians affiliated with a single centre were studied cross-sectionally. Information regarding disease variables and drug use were ascertained by interview and chart review. Drug therapy data including dates of treatment and indications for treatment were analysed using Kaplan-Keier life table methods. Among 101 subjects with SLE, 25 MTX treatment episodes were observed in 24 subjects. The period studied totalled 19766 patient-days, with a median (range) duration of observed MTX treatment of 14.4 (5.1-41.6) months. The median (range) initial and peak MTX doses with 7.5 (2.5-10)mg/wk and 10 (7.5-15) mg/week respectively. The principal indication for commencing methotrexate therapy was arthritis. Only two subjects terminated treatment for toxicity, with the most common reason for termination being remission. The cumulative pro...Continue Reading

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Citations

Apr 20, 2001·Arthritis and Rheumatism·R W McMurray
Nov 15, 1997·Rheumatic Diseases Clinics of North America·W S Wilke
Mar 19, 2002·Pediatrics International : Official Journal of the Japan Pediatric Society·Yukoh AiharaShumpei Yokota
Feb 14, 2012·International Journal of Rheumatic Diseases·Md Nazrul IslamJohannes J Rasker
Jun 26, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S J Morton, R J Powell
Aug 24, 1999·Postgraduate Medicine·R P Sheon
Oct 20, 2015·Expert Opinion on Pharmacotherapy·M W P Tsang-A-Sjoe, I E M Bultink
Jun 10, 2009·Expert Opinion on Pharmacotherapy·Lisa Francis, Andras Perl
Mar 1, 2006·Rheumatic Diseases Clinics of North America·Mary Anne Dooley, Ellen M Ginzler
Mar 9, 2005·Lupus·J M Wong, J M Esdaile
Mar 26, 2003·The American Journal of Gastroenterology·Oliver Schröder, Jürgen Stein
Oct 14, 2017·Rheumatology·Caroline GordonUNKNOWN British Society for Rheumatology Standards, Audit and Guidelines Working Group

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