Methotrexate versus traditional Chinese medicine in psoriasis: a randomized, placebo-controlled trial to determine efficacy, safety and quality of life

Clinical and Experimental Dermatology
S G Y HoH H L Chan

Abstract

Psoriasis is a common and chronic immune-mediated skin disorder, for which there is currently no cure. To our knowledge, this is the first randomized placebo-controlled trial comparing methotrexate and traditional Chinese medicine (TCM) in terms of efficacy, safety, and quality of life for the treatment of psoriasis. In total, 61 patients with moderate to severe plaque psoriasis were randomized to receive treatment with methotrexate, TCM or placebo for 6 months. The primary outcome measure was the Psoriasis Area and Severity Index (PASI), and secondary outcome measures were the Physician's Global Assessment (PGA) and the Psoriasis Disability Index (PDI). In all, 50 patients completed the study and were included in the analysis. Dropout rates were highest in the TCM group. Mean PASI change from baseline at 6 months revealed an improvement of 73.9% of the methotrexate group, 15.1% of the TCM group and 32.0% of the placebo group. There was a significant difference between the three groups, with methotrexate showing greater effectiveness than the other two groups. No significant difference was found between the TCM and placebo groups. The methotrexate group also had greater improvement when assessed using the PGA and PDI. Our resul...Continue Reading

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References

Dec 1, 1990·The British Journal of Dermatology·A Y FinlayM S Salek
Mar 31, 1998·Journal of the American Academy of Dermatology·H H RoenigkM Lebwohl
Nov 26, 1998·Archives of Dermatology·J Koo, S Arain
Sep 1, 1999·The British Journal of Dermatology·D M AshcroftC E Griffiths
Jun 14, 2002·Journal of the American Academy of Dermatology·Harold S JavitzSusan Gillis Vallow
Aug 15, 2003·The New England Journal of Medicine·Vera M R HeydendaelMenno A de Rie
Sep 3, 2003·Clinical and Experimental Dermatology·T W Tse
Aug 1, 1958·A.M.A. Archives of Dermatology·W F EDMUNDSON, W B GUY
Oct 23, 2003·Dermatology : International Journal for Clinical and Investigative Dermatology·E Ben-AryeD Rosenman
Sep 25, 2004·Journal of the American Academy of Dermatology·Richard G Langley, Charles N Ellis
Aug 12, 2006·Dermatology : International Journal for Clinical and Investigative Dermatology·Jochen M Schmitt, Daniel E Ford
Oct 21, 2006·Journal of the American Academy of Dermatology·Andrea L NeimannJoel M Gelfand
Apr 17, 2007·Journal of the American Academy of Dermatology·Hilal Maradit KremersSherine E Gabriel
Jun 26, 2007·Dermatology : International Journal for Clinical and Investigative Dermatology·Jochen M Schmitt, Daniel E Ford
Jul 31, 2007·Lancet·Christopher Em Griffiths, Jonathan Nwn Barker
Dec 19, 2007·Archives of Dermatology·Joel M GelfandBrian L Strom
Aug 30, 2008·Clinics in Dermatology·Richard B Warren, Christopher E M Griffiths

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Citations

Apr 3, 2012·Chinese Journal of Integrative Medicine·Brian H MayCharlie C L Xue
Nov 22, 2014·Dermatologic Clinics·John B KellyBruce E Strober
Jul 11, 2013·Clinical and Experimental Dermatology·S Dogra, R Mahajan
Mar 13, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·T C LuckaA Nast
Jul 2, 2016·The Journal of Dermatological Treatment·Shefton ParkerCharlie C Xue
Jan 10, 2020·The Cochrane Database of Systematic Reviews·Emilie SbidianLaurence Le Cleach
Aug 7, 2019·Experimental and Therapeutic Medicine·Jiangtao Guo, Jie Liu
Feb 6, 2017·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Benjamin FarahnikRaja Sivamani
Dec 23, 2017·The Cochrane Database of Systematic Reviews·Emilie SbidianLaurence Le Cleach
May 9, 2019·Revista da Associação Médica Brasileira·Marcelo ArnoneWanderley M Bernardo
Dec 14, 2018·Experimental and Therapeutic Medicine·Wenjun GengShaohua Qiao
Apr 20, 2021·The Cochrane Database of Systematic Reviews·Emilie SbidianLaurence Le Cleach

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