PMID: 6968621Nov 1, 1980Paper

Methotrexate/L-asparaginase combination chemotherapy for patients with acute leukemia in relapse: a study of 36 children

Cancer
R E HarrisR L Baehner

Abstract

Cyclic administration of methotrexate (MTX) and L-Asparaginase (L-Asp) was utilized either as induction and maintenance chemotherapy or as maintenance chemotherapy alone following induction with other medications in treating 36 children with multiple relapses of acute leukemia. A complete remission rate (CR) of 67% was obtained in children with null-cell acute lymphocytic leukemia (ALL). The average length of remission was greater than four months. One of three patients with T-cell ALL and one of two patients with B-cell ALL achieved CR. In six cases of acute nonlymphocytic leukemia (ANLL), two patients achieved CR. One of two patients with terminal deoxynucleotidyl transferase (TdT) negative myeloblastic transformation of Ph'-positive chronic myelogenous leukemia (CML) obtained a CR lasting 20 weeks. Toxicity secondary to the chemotherapy included bone marrow suppression, hepatic injury, nausea, diarrhea, stomatitis, and allergic reactions to L-Asp. One case of subacute necrotizing leukoencephalopathy was seen.

Citations

Oct 13, 1998·Critical Reviews in Oncology/hematology·H J Müller, J Boos
Apr 30, 2002·Medical and Pediatric Oncology·Birgitte Klug AlbertsenNiels T Carlsen
Jul 1, 1983·Disease-a-month : DM·S A Liebhaber, C S Manno
Jan 1, 1983·Critical Reviews in Oncology/hematology·L P Miller, D R Miller
Feb 1, 1983·Drug Intelligence & Clinical Pharmacy·T GravesT H Guthrie
Apr 8, 1983·Journal of Chromatography·S L Pahuja, T W Reid

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