PMID: 6102854Jan 1, 1980

Methoxyethylmercury nephrotoxicity: effects on enzymuria and kidney function

Archives of Toxicology
V Burgat-SacazeB Eghbali

Abstract

The fungicide, methoxyethylmercury chloride, was given in a saline solution to four groups of Sprague-Dawley C D rats (5 male, 5 female) as a single injection (IP) of 0, 0.5, 1.0, and 2.0 mg Hg/kg. In a three-day period, no changes were observed in urine collected every 24 h from rats given 0 or 0.5 mg Hg/kg; 1 mg Hg/kg induced only a transient increase of urine gamma glutamyl transferase (x 4) and alkaline phsophatase (x 2.5) on the day 2; 2.0 mg Hg/kg caused an early increase of enzymuria (day 1 and day 2) and a decrease of Na+, Cl-, K+, urea, and creatinin excretion. Urine enzymes and total mercury excretion were higher in males. These time-related variations of enzymuria, compared to previous results with Hg Cl2, could reflect the existence of metabolites more toxic than the native compound.

References

Jan 1, 1977·Biochemical Society Transactions·R J PierceJ S Fowler
Jan 30, 1976·Archives of Toxicology·L Magos, W H Butler
Mar 1, 1976·Acta Pharmacologica Et Toxicologica·N Gyrd-Hansen, A Helleberg
Oct 1, 1972·The Biochemical Journal·J W DanielP A Lefevre
Feb 1, 1971·The Biochemical Journal·J W DanielP A Lefevre

Citations

Aug 3, 1981·Klinische Wochenschrift·F KellerG Schultze
Jan 1, 1982·Toxicology·R G Price
Jun 1, 1982·Journal of Toxicology. Clinical Toxicology·C KöppelF Keller

Related Concepts

Neanthine, 14C-labeled cpd
Alkaline Phosphatase
Granosan
Ethylmercury Compounds
Gamma-glutamyl transferase
Kidney
Kidney Diseases
Kidney Function Tests
Renal Tubule Structure
Mercury

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