PMID: 4895338Aug 2, 1969Paper

Methoxyflurane and nitrous oxide as obstetric analgesics. I. A comparison by continuous administration

British Medical Journal
P L JonesE V Jones

Abstract

Methoxyflurane and nitrous oxide have been compared as obstetric analgesics. The inhaled concentrations of these agents, given continuously, were adjusted by an anaesthetist to maintain each patient at the optimum state between reaction to pain and consciousness. Assessments were made continuously.Though the anaesthetist's assessment showed no difference between the mean results, a greater proportion of the methoxyflurane patients were "satisfactory" for 90-100% of the time than of the nitrous oxide patients, particularly in regard to objective pain relief. The midwives' opinion of those who had "complete" pain relief supported this. Nausea was significantly less among methoxyflurane patients, and vomiting during labour occurred only in patients who had nitrous oxide. It is concluded that nitrous oxide and methoxyflurane given in a continuously adjusted concentration are almost equally effective as obstetric analgesics, though there are certain features which favour methoxyflurane.

References

Dec 24, 1966·British Medical Journal·V MajorW W Mushin
Jan 1, 1960·The Journal of Pharmacology and Experimental Therapeutics·J PARKHOUSEH P ROME

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Citations

May 1, 1970·Canadian Anaesthetists' Society Journal·A RomagnoliD J Power
Aug 24, 2004·International Journal of Obstetric Anesthesia·A ToscanoV A Peduto
Mar 14, 2013·Iranian Red Crescent Medical Journal·Hajar PashaHajar Salmalian
Dec 6, 2011·Gastrointestinal Endoscopy·Magnus LøbergMichael Bretthauer
Nov 7, 2015·Saudi Journal of Anaesthesia·Jamil S AnwariAbdullah S Terkawi
May 16, 2002·American Journal of Obstetrics and Gynecology·Mark A Rosen
Dec 21, 2013·Anesthesia and Analgesia·Frances E LikisMelissa L McPheeters
Jan 31, 2017·Anesthesiology Clinics·Michael G RichardsonCurtis L Baysinger
Dec 22, 2016·Anesthesia and Analgesia·Michael G RichardsonDavid H Chestnut
Sep 14, 2012·The Cochrane Database of Systematic Reviews·Trudy KlompAntoine L M Lagro-Janssen
Jan 1, 1984·Anaesthesia·C McGuinness, M Rosen
Apr 1, 2011·Current Opinion in Anaesthesiology·Petri VolmanenJouni Ahonen

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