PMID: 4895339Aug 2, 1969Paper

Methoxyflurane and nitrous oxide as obstetric analgesics. II. A comparison by self-administered intermittent inhalation

British Medical Journal
P L JonesE V Jones

Abstract

Methoxyflurane (0.35%) in air and nitrous oxide/oxygen (50%/50%) self-administered intermittently in the usual way have been compared as analgesics for labour. There were 25 patients in each group. Objective assessment by an anaesthetist showed that methoxyflurane is the more effective analgesic, and this was supported by the opinion of the multiparae. Nausea and vomiting were significantly less with methoxyflurane. Fifty per cent. nitrous oxide in oxygen given intermittently does not appear to be the best analgesic concentration. Nevertheless, since a considerable variation in sensitivity exists, it would probably be unwise to consider the introduction of higher concentrations for use by unsupervised midwives.This trial confirms the predictions made by us using a method for screening inhalational analgesics, in which methoxyflurane and nitrous oxide were given continuously.

References

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Citations

May 1, 1970·Canadian Anaesthetists' Society Journal·A RomagnoliD J Power
Aug 24, 2004·International Journal of Obstetric Anesthesia·A ToscanoV A Peduto
Feb 1, 1995·Acta Anaesthesiologica Scandinavica·T K AbboudK Yakal
Jan 8, 1972·British Medical Journal·M RosenA W Asscher
Mar 14, 2013·Iranian Red Crescent Medical Journal·Hajar PashaHajar Salmalian
Jun 13, 2009·High Altitude Medicine & Biology·Jeremy WindsorGeorge Rodway
Nov 7, 2015·Saudi Journal of Anaesthesia·Jamil S AnwariAbdullah S Terkawi
May 16, 2002·American Journal of Obstetrics and Gynecology·Mark A Rosen
Dec 21, 2013·Anesthesia and Analgesia·Frances E LikisMelissa L McPheeters
Jan 31, 2017·Anesthesiology Clinics·Michael G RichardsonCurtis L Baysinger
Dec 22, 2016·Anesthesia and Analgesia·Michael G RichardsonDavid H Chestnut
Sep 14, 2012·The Cochrane Database of Systematic Reviews·Trudy KlompAntoine L M Lagro-Janssen
Aug 18, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Vincenzo ZanardoGianluca Straface
Jun 24, 2015·Australian Dental Journal·A KingonM McCullough
Nov 1, 1972·Anaesthesia and Intensive Care·J O'Leary
Jan 1, 1984·Anaesthesia·C McGuinness, M Rosen

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