Methuselah meets diabetes

BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology
J H Thomas, T Inoue

Abstract

Mutations in the daf-2 and age-1 genes cause constitutive dauer larva formation and double adult life span in C. elegans. Their effect on life span has excited considerable interest and their effect on dauer formation has facilitated rapid progress in their genetic and molecular analysis. Two recent papers report that daf-2 encodes a member of the insulin-receptor family and that age-1 encodes a PI3 kinase subunit, a second-messenger producing enzyme known to act downstream of the mammalian insulin receptor. These findings provide the first mechanistic insight into the well-established link between metabolism and aging.

References

Dec 3, 1992·Nature·W A Van Voorhies
Aug 1, 1994·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R Kapeller, L C Cantley
Dec 1, 1993·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J H Thomas
Jan 1, 1996·Annual Review of Medicine·C R KahnA Doria

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Citations

Jul 17, 2003·International Journal for Parasitology·John M Hawdon, Bennett Datu
Jan 9, 2001·Trends in Ecology & Evolution·A M Leroi
Jul 27, 2000·Annals of the New York Academy of Sciences·G McCollG J Lithgow

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