Methyl 2-tetradecylglycidate, an orally effective hypoglycemic agent that inhibits long chain fatty acid oxidation selectively

PMID: 446909Mar 1, 1979Paper

Methyl 2-tetradecylglycidate, an orally effective hypoglycemic agent that inhibits long chain fatty acid oxidation selectively

Diabetes

G F TutwilerW Ho

Abstract

No abstract listed.

Citations

Mercaptoacetate decreases latency to initiate independent ingestion, but not suckling, in preweanling rats

Sep 5, 2002·Developmental Psychobiology·Susan E Swithers, Melissa McCurley

Phenylalkyloxirane carboxylic acids, a new class of hypoglycaemic substances: hypoglycaemic and hypoketonaemic effects of sodium 2-[5-(4-chlorophenyl)-pentyl]-oxirane-2-carboxylate (B 807-27) in fasted animals

Jun 1, 1982·Diabetologia·H P WolfG Ludwig

The effect of methyl palmoxirate on incorporation of [U-14C]palmitate into rat brain

Sep 1, 1994·Neurochemical Research·M C ChangJ M Bell

The relative contribution of glucose and fatty acids to ATP production in hearts reperfused following ischemia

Oct 21, 1992·Molecular and Cellular Biochemistry·G D Lopaschuk, M Saddik

Inhibition of hepatic lipogenesis by 2-tetradecylglycidic acid.

Oct 1, 1979·Lipids·S A McCuneR A Harris

Effect of the fatty acid oxidation inhibitor 2-tetradecylglycidic acid (TDGA) on glucose and fatty acid oxidation in isolated rat soleus muscle.

Jan 1, 1988·The International Journal of Biochemistry·R W TumanG F Tutwiler

Inhibition of mitochondrial carnitine palmitoyl transferase by 2-tetradecylglycidic acid (McN-3802) (preliminary communication)

Feb 4, 1980·Life Sciences·G F Tutwiler, M T Ryzlak

A new inhibitor of the long-chain fatty acid transfer across the mitochondrial membrane: 2-(3-methylcinnamylhydrazono)-propionate (BM 42.304)

Jan 7, 1985·Life Sciences·F H SchmidtH F Kuhnle

Emeriamine, an antidiabetic beta-aminobetaine derived from a novel fungal metabolite

Jul 22, 1985·Life Sciences·T KanamaruM Yoneda

Diabetes-induced abnormalities in the myocardium

Mar 17, 1986·Life Sciences·A G Tahiliani, J H McNeill

Chronic inhibition of fatty acid oxidation: new model of diastolic dysfunction.

Jan 1, 1989·Life Sciences·R BresslerS Goldman

A quantitative method for measuring regional in vivo fatty-acid incorporation into and turnover within brain phospholipids: review and critical analysis

Sep 1, 1992·Brain Research. Brain Research Reviews·P J RobinsonS I Rapoport

Differential effects of lipoprivation and food deprivation on chow and milk intake in 25- and 30-day-old rats

Jun 2, 2005·Appetite·Susan E SwithersAlicia Doerflinger

Etomoxir, a fatty acid oxidation inhibitor, increases food intake and reduces hepatic energy status in rats

Apr 3, 2004·Physiology & Behavior·Charles C HornMark I Friedman

Metabolic and behavioral responses in pre-weanling rats following alteration of maternal diet

Mar 10, 2001·Physiology & Behavior·S E SwithersR J Davis

Do metabolic signals stimulate intake in rat pups?

Jun 24, 2003·Physiology & Behavior·Susan E Swithers

Effects of 2-mercaptoacetate on ingestive behavior in 18- and 21-day-old rats

Nov 14, 2002·Behavioural Brain Research·Susan E Swithers, Melissa McCurley

Insulin action and substrate competition

Oct 1, 1993·Baillière's Clinical Endocrinology and Metabolism·L C Groop, E Ferrannini

Synthesis of 2-[6-(2,4-dinitrophenoxy)hexyl]oxiranecarboxylic acid: a selective carnitine palmitoyltransferase-1 inhibitor

Jan 9, 1999·Bioorganic & Medicinal Chemistry·T L Hutchison, W J Brouillette

Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research

Apr 21, 2011·Journal of Medicinal Chemistry·Simona M CeccarelliArduino Arduini

Decrease of fatty acid oxidation, ketogenesis and gluconeogenesis in isolated perfused rat liver by phenylalkyl oxirane carboxylate (B 807-27) due to inhibition of CPT I (EC 2.3.1.21)

Jan 15, 1985·European Journal of Biochemistry·H P Wolf, D W Engel

Decrease of food intake in rats after ingestion of medium-chain triacylglycerol

Nov 21, 2009·Journal of Nutritional Science and Vitaminology·Katsuhiko OoyamaHiroyuki Takeuchi

Liver carnitine metabolism after partial hepatectomy in the rat. Effects of nutritional status and inhibition of carnitine palmitoyltransferase

May 20, 1985·FEBS Letters·P S SchofieldM C Sugden

Inhibition of carnitine palmitoyltransferase 1 by phenylalkyloxiranecarboxylic acid and its influence on lipolysis and glucose metabolism in isolated, perfused hearts of streptozotocin-diabetic rats

Feb 1, 1984·Metabolism: Clinical and Experimental·P Rösen, H Reinauer

Mechanisms of the glucose lowering effect of a carnitine palmitoyl transferase inhibitor in normal and diabetic rats

Apr 1, 1991·Metabolism: Clinical and Experimental·C MartinM Beylot

Effects of intravenous methyl palmoxirate on the turnover and oxidation of fatty acids in conscious dogs

Apr 1, 1991·Metabolism: Clinical and Experimental·J W BaileyJ M Miles

Inhibition by etomoxir of carnitine palmitoyltransferase I reduces hepatic glucose production and plasma lipids in non-insulin-dependent diabetes mellitus

Nov 1, 1991·Metabolism: Clinical and Experimental·K RatheiserH P Wolf

Prevention of the metabolic effects of 2-tetradecylglycidate by octanoic acid in the genetically diabetic mouse (db/db)

Feb 1, 1985·Biochemical Medicine·S M LeeR Bressler

Hypoglycaemic and hypoketonaemic effects of single and repeated oral doses of methyl palmoxirate (methyl 2-tetradecylglycidate) in streptozotocin/alloxan-induced diabetic dogs

May 1, 1988·British Journal of Pharmacology·R W TumanN H Wallace

Alterations of drug-induced toxicity in the mouse lymphoma assay by a rat hepatic microsomal metabolizing system (S-9)

Jun 1, 1984·Journal of Applied Toxicology : JAT·J W OldhamJ F Pritchard

The effect of methyl-2-tetradecylglycidate (McNeil 3716) on heart mitochondrial metabolism in rats

Jun 15, 1984·Biochemical Pharmacology·E BachmannG Zbinden

Effect of the oral hypoglycemic agent 2-tetradecylglycidic acid on fatty acid oxidation in suckling rats in vivo and in perfused liver

Oct 15, 1981·Archives of Biochemistry and Biophysics·S C Frost, M A Wells

Recirculating, retrograde heart perfusion according to the Langendorff method for evaluation of MTG--methyl-2-tetradecylglycidate, McNeil 3716--cardiomyopathy

Feb 1, 1993·Pharmacology & Toxicology·E Bachmann, E Weber

Induction of myocardial hypertrophy after coronary ligation in rats decreases ventricular dilatation and improves systolic function

Oct 1, 1991·Circulation·S E LitwinS Goldman

Impact of in vivo fatty acid oxidation blockade on glucose turnover and muscle glucose metabolism during low-dose AICAR infusion

Jun 15, 2006·American Journal of Physiology. Endocrinology and Metabolism·Michael ChristopherFrank P Alford

Fatty acid oxidation affects food intake by altering hepatic energy status

Apr 13, 1999·The American Journal of Physiology·M I FriedmanM G Tordoff

Relation of oxidation of long-chain fatty acids to gluconeogenesis in the perfused liver of the guinea pig: effect of 2-tetradecylglycidic acid (McN-3802)

Jun 1, 1982·European Journal of Biochemistry·G F Tutwiler, H J Brentzel

Effects of subbasal insulin infusion on resting and exercise-induced glucose turnover in depancreatized dogs

Mar 1, 1993·The American Journal of Physiology·Z Q ShiM Vranic

Development of independent ingestive responding to blockade of fatty acid oxidation in rats

Dec 31, 1997·The American Journal of Physiology·S E Swithers

Contribution of muscle and liver to glucose-fatty acid cycle in humans

Apr 1, 1993·The American Journal of Physiology·C SalorantaL Groop

Role of FFA-glucose cycle in glucoregulation during exercise in total absence of insulin

Oct 1, 1992·The American Journal of Physiology·K YamataniM Vranic

Glucose is required to maintain ATP/ADP ratio of isolated bovine cerebral microvessels.

Mar 1, 1990·The American Journal of Physiology·C G GaposchkinA L McCall

Glucose and fatty acid metabolism in normal and diabetic rabbit cerebral microvessels

May 1, 1987·The American Journal of Physiology·V Hingorani, P Brecher

In vitro and in vivo suppression of gluconeogenesis by inhibition of pyruvate carboxylase

Jan 10, 1997·Biochemical Pharmacology·J J BahlR Bressler

Effect of methyl palmoxirate, an oral hypoglycemic agent, on epinephrine-induced hyperglycemia in the rat

Jun 15, 1985·Biochemical Pharmacology·G F TutwilerN Wallace

Long-term administration of a sucrose-rich diet to normal rats: relationship between metabolic and hormonal profiles and morphological changes in the endocrine pancreas

Dec 1, 1996·Metabolism: Clinical and Experimental·Y B LombardoC L Gomez Dumm

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Methyl 2-tetradecylglycidate, an orally effective hypoglycemic agent that inhibits long chain fatty acid oxidation selectively

Abstract

Citations

Mercaptoacetate decreases latency to initiate independent ingestion, but not suckling, in preweanling rats

Phenylalkyloxirane carboxylic acids, a new class of hypoglycaemic substances: hypoglycaemic and hypoketonaemic effects of sodium 2-[5-(4-chlorophenyl)-pentyl]-oxirane-2-carboxylate (B 807-27) in fasted animals

The effect of methyl palmoxirate on incorporation of [U-14C]palmitate into rat brain

The relative contribution of glucose and fatty acids to ATP production in hearts reperfused following ischemia

Inhibition of hepatic lipogenesis by 2-tetradecylglycidic acid.

Effect of the fatty acid oxidation inhibitor 2-tetradecylglycidic acid (TDGA) on glucose and fatty acid oxidation in isolated rat soleus muscle.

Inhibition of mitochondrial carnitine palmitoyl transferase by 2-tetradecylglycidic acid (McN-3802) (preliminary communication)

A new inhibitor of the long-chain fatty acid transfer across the mitochondrial membrane: 2-(3-methylcinnamylhydrazono)-propionate (BM 42.304)

Emeriamine, an antidiabetic beta-aminobetaine derived from a novel fungal metabolite

Diabetes-induced abnormalities in the myocardium

Chronic inhibition of fatty acid oxidation: new model of diastolic dysfunction.

A quantitative method for measuring regional in vivo fatty-acid incorporation into and turnover within brain phospholipids: review and critical analysis

Differential effects of lipoprivation and food deprivation on chow and milk intake in 25- and 30-day-old rats

Etomoxir, a fatty acid oxidation inhibitor, increases food intake and reduces hepatic energy status in rats

Metabolic and behavioral responses in pre-weanling rats following alteration of maternal diet

Do metabolic signals stimulate intake in rat pups?

Effects of 2-mercaptoacetate on ingestive behavior in 18- and 21-day-old rats

Insulin action and substrate competition

Synthesis of 2-[6-(2,4-dinitrophenoxy)hexyl]oxiranecarboxylic acid: a selective carnitine palmitoyltransferase-1 inhibitor

Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research

Decrease of fatty acid oxidation, ketogenesis and gluconeogenesis in isolated perfused rat liver by phenylalkyl oxirane carboxylate (B 807-27) due to inhibition of CPT I (EC 2.3.1.21)

Decrease of food intake in rats after ingestion of medium-chain triacylglycerol

Liver carnitine metabolism after partial hepatectomy in the rat. Effects of nutritional status and inhibition of carnitine palmitoyltransferase

Inhibition of carnitine palmitoyltransferase 1 by phenylalkyloxiranecarboxylic acid and its influence on lipolysis and glucose metabolism in isolated, perfused hearts of streptozotocin-diabetic rats

Mechanisms of the glucose lowering effect of a carnitine palmitoyl transferase inhibitor in normal and diabetic rats

Effects of intravenous methyl palmoxirate on the turnover and oxidation of fatty acids in conscious dogs

Inhibition by etomoxir of carnitine palmitoyltransferase I reduces hepatic glucose production and plasma lipids in non-insulin-dependent diabetes mellitus

Prevention of the metabolic effects of 2-tetradecylglycidate by octanoic acid in the genetically diabetic mouse (db/db)

Hypoglycaemic and hypoketonaemic effects of single and repeated oral doses of methyl palmoxirate (methyl 2-tetradecylglycidate) in streptozotocin/alloxan-induced diabetic dogs

Alterations of drug-induced toxicity in the mouse lymphoma assay by a rat hepatic microsomal metabolizing system (S-9)

The effect of methyl-2-tetradecylglycidate (McNeil 3716) on heart mitochondrial metabolism in rats

Effect of the oral hypoglycemic agent 2-tetradecylglycidic acid on fatty acid oxidation in suckling rats in vivo and in perfused liver

Recirculating, retrograde heart perfusion according to the Langendorff method for evaluation of MTG--methyl-2-tetradecylglycidate, McNeil 3716--cardiomyopathy

Induction of myocardial hypertrophy after coronary ligation in rats decreases ventricular dilatation and improves systolic function

Impact of in vivo fatty acid oxidation blockade on glucose turnover and muscle glucose metabolism during low-dose AICAR infusion

Fatty acid oxidation affects food intake by altering hepatic energy status

Relation of oxidation of long-chain fatty acids to gluconeogenesis in the perfused liver of the guinea pig: effect of 2-tetradecylglycidic acid (McN-3802)

Effects of subbasal insulin infusion on resting and exercise-induced glucose turnover in depancreatized dogs

Development of independent ingestive responding to blockade of fatty acid oxidation in rats

Contribution of muscle and liver to glucose-fatty acid cycle in humans

Role of FFA-glucose cycle in glucoregulation during exercise in total absence of insulin

Glucose is required to maintain ATP/ADP ratio of isolated bovine cerebral microvessels.

Glucose and fatty acid metabolism in normal and diabetic rabbit cerebral microvessels

In vitro and in vivo suppression of gluconeogenesis by inhibition of pyruvate carboxylase

Effect of methyl palmoxirate, an oral hypoglycemic agent, on epinephrine-induced hyperglycemia in the rat

Long-term administration of a sucrose-rich diet to normal rats: relationship between metabolic and hormonal profiles and morphological changes in the endocrine pancreas

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Pharmacologic profile of methyl 2-tetradecylglycidate (McN-3716)--an orally effective hypoglycemic agent

Behavioral specificity of effects of 2-mercaptoacetate on independent ingestion in developing rats

Inhibition of mitochondrial carnitine palmitoyl transferase by 2-tetradecylglycidic acid (McN-3802) (preliminary communication)

Mechanism of hyperglycemia and response to treatment with an inhibitor of fatty acid oxidation in a patient with insulin resistance due to antiinsulin receptor antibodies

Mercaptoacetate decreases latency to initiate independent ingestion, but not suckling, in preweanling rats