Methyl aminolevulinate plus red light vs. placebo plus red light in the treatment of photodamaged facial skin: histopathological findings

Clinical and Experimental Dermatology
G SanclementeH I Garcia

Abstract

Improvement in the morphological appearance of collagen and elastic fibres has been reported after the use of trichloroacetic acid, dermabrasion and laser therapy, but the histopathological changes occurring after photodynamic therapy are less understood. To assess the histological changes that occur after methyl aminolevulinate (MAL) plus red-light therapy for facial photodamage. This was a prospective, double-blind, double-arm, randomized, placebo-controlled trial of MAL plus red light in patients with facial photodamage. A 3-mm punch biopsy was taken from each side of the face before randomization and start of therapy. A dermatopathologist blinded to the treatment assessed epidermal and dermal layer thickness, perivascular inflammation, solar elastosis, perifollicular fibrosis, telangiectasias, number of elastic and collagen fibres, and grade of reticular degeneration. In total, 65 women were initially screened for eligibility, but skin samples from only 38 of these were analysed. The change in dermal thickness from baseline to postintervention was significant (P < 0.01, Wilcoxon signed rank test). Although there was a trend for the epidermis to be thinner after MAL plus red light vs. placebo plus red light (46.25 μm vs. 55....Continue Reading

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Citations

Jun 23, 2015·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Jenifer Mendoza-GarciaArdeshir Bayat
Feb 28, 2015·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Daniel P FriedmannIsabella Guiha
Apr 8, 2015·Photodermatology, Photoimmunology & Photomedicine·Jenifer Mendoza-GarciaArdeshir Bayat
Apr 30, 2016·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Daniel P Friedmann, Mitchel P Goldman
Feb 25, 2020·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Alisen HuangJared Jagdeo
Jun 20, 2020·Dermatology : International Journal for Clinical and Investigative Dermatology·Giuseppe MonfrecolaPiergiacomo Calzavara-Pinton

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