Methyl beta-carboline-3-carboxylate enhances performance in a multiple-trial learning task in mice

Pharmacology, Biochemistry, and Behavior
M J Raffalli-SebilleR H Dodd

Abstract

In contrast to diazepam, a benzodiazepine receptor (BZ-R) ligand, which impairs memory processing, methyl beta-carboline-3-carboxylate (beta-CCM), another BZ-R ligand, administered before a training session, enhances performance in a retention test. This action, however, has only been demonstrated in single trial or single session learning protocols. The present report extends these results to a multiple-trial learning procedure in mice (brightness discrimination in a T-maze with negative reinforcement). The animals were trained for sessions of ten trials per day for six consecutive days. In a first experiment, the sessions during the first three days took place after administration of beta-CCM (0.3 mg/kg), diazepam (2.5 mg/kg) or saline. In a second experiment, especially designed to study the effects of beta-CCM, during the first three days animals received beta-CCM (0.3 mg/kg), Ro 15-1788 (15 mg/kg), beta-CCM + Ro 15-1788, vehicles of these drugs or saline. In the first experiment, performance was improved by beta-CCM and impaired by diazepam in the first three sessions as well as in the final three. In the second experiment, beta-CCM alone, as well as Ro 15-1788 improved performance, and the simultaneous administration of t...Continue Reading

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Citations

Oct 1, 1993·Pharmacology, Biochemistry, and Behavior·G R WengerD W Wright
Mar 1, 1994·Pharmacology, Biochemistry, and Behavior·A V TitievskyM M Airaksinen
Mar 20, 2002·Pharmacology, Biochemistry, and Behavior·Jean-Claude Do-RegoJean Costentin
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Sep 15, 2010·Life Sciences·Sunita SharmaHolly Brown-Borg
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Aug 11, 2012·Behavioural Brain Research·Janko SamardžićDragan I Obradović
Feb 13, 2021·Seminars in Cell & Developmental Biology·Joan Jiménez-Balado, Teal S Eich

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