Methyl brevifolincarboxylate, a novel influenza virus PB2 inhibitor from Canarium Album (Lour.) Raeusch.

Chemical Biology & Drug Design
Fangzhao ChenJie Yang

Abstract

Methyl brevifolincarboxylate (MBC) was isolated from ethyl acetate extract of Canarium album (Lour.) Raeusch. The structure was identified, and the effect on influenza A virus infection was evaluated. MBC exhibited inhibitory activity against influenza virus A/Puerto Rico/8/34 (H1N1) and A/Aichi/2/68 (H3N2) with IC50 values of 27.16 ± 1.39 μM and 33.41 ± 2.34 μM. Mechanism studies indicated that MBC inhibited the replication of influenza A virus by targeting PB2 cap-binding domain. Our results demonstrated MBC was a potent PB2 cap-binding inhibitor and represented as a new type of promising lead compound for the development of anti-influenza virus drugs from natural products.

References

Feb 25, 2005·Antimicrobial Agents and Chemotherapy·Yousuke FurutaKimiyasu Shiraki
Dec 24, 2005·The New England Journal of Medicine·Anne Moscona
Sep 2, 2006·Virology Journal·Mikhail MatrosovichHans-Dieter Klenk
May 6, 2008·Nature Structural & Molecular Biology·Delphine GuilligayStephen Cusack
Feb 6, 2009·Emerging Infectious Diseases·Siri H HaugeOlav Hungnes
Apr 28, 2009·Virology·Martha I NelsonEdward C Holmes
May 4, 2011·European Journal of Pharmacology·Shuwen LiuBojian Zheng
Jun 23, 2011·Expert Review of Anti-infective Therapy·Jacqueline M KatzXiyan Xu
Mar 1, 2012·Annals of Internal Medicine·Jonathan HsuHolger J Schünemann
Aug 13, 2013·Current Medicinal Chemistry·Fangyuan ShiWenfang Xu
Oct 19, 2013·Journal of Medicinal Chemistry·Stéphane PautusStephen Cusack
Apr 5, 2014·Cellular and Molecular Life Sciences : CMLS·Arianna LoregianGiorgio Palù
Nov 25, 2014·Nature Reviews. Microbiology·Amie J EisfeldYoshihiro Kawaoka
Apr 29, 2015·Antimicrobial Agents and Chemotherapy·Shuofeng YuanBo-Jian Zheng
Sep 10, 2015·The American Journal of Tropical Medicine and Hygiene·Haiying ChenMing Liao
Nov 19, 2015·Acta Pharmaceutica Sinica. B·Zuyuan ShenWei Wang
Jun 9, 2016·The Journal of Antimicrobial Chemotherapy·Shuofeng YuanBo-Jian Zheng
Apr 19, 2017·Journal of Agricultural and Food Chemistry·Richan LiJie Yang
Apr 7, 2018·Journal of Natural Medicines·Luo-Ping YangWen-Jun Duan
Sep 6, 2018·The New England Journal of Medicine·Frederick G HaydenUNKNOWN Baloxavir Marboxil Investigators Group
Sep 12, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ning-Ning ZhangShao-Xiao Zeng
Dec 18, 2019·Biochemical and Biophysical Research Communications·Fangzhao ChenJie Yang

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Citations

Feb 14, 2021·Antiviral Research·Mira C PatelLarisa V Gubareva
Jan 21, 2022·Journal of Agricultural and Food Chemistry·Jiming LiXiangjiu He

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