PMID: 6539161Jul 15, 1984Paper

Methyl-CCNU, doxorubicin, and cis-diamminedichloroplatinum II in the management of recurrent and metastatic squamous carcinoma of the cervix

Cancer
J A CarlsonB J Masterson

Abstract

Twenty-three patients with recurrent unresectable carcinoma of the cervix or distant metastasis at initial presentation were treated with methyl-CCNU (175 mg/m2) and doxorubicin (45 mg/m2) on day 1 and cis- diamminedichloroplatinum II (90 mg/m2) on day 22 of a 42-day treatment cycle. Twenty-two patients had squamous carcinoma and 1 had adenosquamous carcinoma. There were two complete responses (CR), five partial responses (PR) (greater than 50% tumor reduction, greater than 3-month duration), four patients with stable disease (less than 50% reduction, greater than 3-month duration), and 12 patients who had tumor progression. One CR has been maintained greater than 28 months, and the other greater than 8 months. Total CR and PR was 7 of 23 (30.4%). Three 23 responses occurred among 15 patients (20%) who had cancer primarily confined to the pelvis, while 4 of 8 patients (50%) with distant metastasis responded. During the initial 2 cycles of chemotherapy, 12 patients had myelosuppression, defined as a leukocytes less than 3000/mm3, granulocytes less than 1,000/mm3, or platelets less than 100,000/mm3. There were no treatment-related deaths.

References

May 24, 1979·The New England Journal of Medicine·W E HarmonW E Grupe
Apr 1, 1978·American Journal of Obstetrics and Gynecology·C J CohenH W Bruckner
Nov 1, 1978·American Journal of Obstetrics and Gynecology·T G DayF N Rutledge
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Oct 1, 1981·American Journal of Obstetrics and Gynecology·D J HallD R Goplerud

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Citations

Oct 15, 1987·Cancer·T ThigpenR McGehee

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